Results 101 to 110 of about 11,026,292 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Assessing the Productive Efficiency of Non-Profit Organisations: a Comparative Analysis [PDF]
Empirical evidence on the productive efficiency of non-profit organisations is at present scarce and not conclusive. In the present work, we analyse this issue by relying on a new data-set about Italian for-profit and non-profit organisations engaged in ...
DESTEFANIS, Sergio +1 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 1999 Il contributo analizza l'importanza della gestione finanzairia delle aziende non profit, sottolineando le criticità legate all'equilibrio finanziario e alla ricerca di differenti fonti di ...
Maioli G. +3 more
core
The Governance of Not-For-Profit Firms [PDF]
Many factors including incentive-pay, powerful shareholders, and takeover threats push for-profits managers towards maximizing shareholder value.
Edward L. Glaeser
core +2 more sources
Acta Medica LeopoliensiaAim. Accessibility, timeliness, and patient-centered approach are among the main elements in ensuring the quality of medical care; therefore, the aim of the study was to analyze and process epidemiological data on certain nosological entities of ...
Taras Gutor +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Львівський клінічний вісникntroduction. To analyze clinical, laboratory, anthropometric, and molecular-genetic characteristics of patients with lipid metabolism disorders and to assess the potential significance of the APOC3 rs5128, PON1 rs662, and APOE rs769452 variants in the ...
Р. К. Жураєв +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2007 Through qualitative in-depth semi-structure interviews with 35 senior non-profit executives in 22 Non-Profit Organisations (NPOs) in Australia, it was found that Human Capital (HC) and Human Resource Management (HRM) were perceived to be identical and ...
Kong, Eric
core +1 more source