Results 121 to 130 of about 11,026,292 (311)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Canadian Government – Non-Profit Relations and COVID-19: Crisis and the Non-Profit Sector [PDF]
This study examines the state of the non-profit sector during the ongoing COVID-19 pandemic through the context of government-non-profit relations. The history of this relationship is essential to the understanding of why the non-profit sector has been ...
Youness, Safa
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Львівський клінічний вісникIntroduction. Basal cell carcinoma in most cases remains localized in the superficial layers of the skin, without penetrating into deeper tissues.
А. Р. Вергун +6 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Le specificità delle organizzazioni e imprese non profit
, 2004 Nel contributo vengono schematicamente presentate alcune delle specificità delle organizzazioni e imprese non ...
A. ZANGRANDI, MATACENA, ANTONIO
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Finanziamenti e appalti: i rapporti tra aziende non profit e aziende pubbliche
, 2003 Analisi del rapporto tra amministarzioni pubbliche ed aziende non profit: processi di acquisto ed ...
AMATUCCI, Fabio Michele
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Український журнал серцево-судинної хірургіїAim. To identify the age- and smoking-related histopathological changes in the internal thoracic artery (ITA) in patients with coronary artery disease (CAD). Materials and Methods. A histopathological study was performed on cross-sections of discarded
Tetiana M. Solomenchuk +2 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source