Results 161 to 170 of about 805,503 (353)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

NON-PROFIT FOOD CENTERS IN TENNESSEE: SURVEY FINDINGS [PDF]

Agribusiness,
Godwin, Sandria L., Speller-Henderson, Leslie, Tegegne, Fisseha   +2 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Association of COVID-19-Related Restrictions With Changes in Functional Skills of Adults With Intellectual Disabilities in Day Programs of an Israeli Non-Profit Organization. [PDF]

Res Pract Persons Severe Disabl, 2023
Ben David N, Lotan M, Moran DS.
europepmc   +1 more source

Assessing the Productive Efficiency of Non-Profit Organisations: a Comparative Analysis [PDF]

Empirical evidence on the productive efficiency of non-profit organisations is at present scarce and not conclusive. In the present work, we analyse this issue by relying on a new data-set about Italian for-profit and non-profit organisations engaged in ...
DESTEFANIS, Sergio, MAIETTA, Ornella Wanda   +1 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Non-profit research: an insight into the management and monitoring of clinical trials in Italy. [PDF]

Glob Reg Health Technol Assess
Tizi F, Appolloni V, Bonifacio B, Tommasi S, Lega S, Cagnazzo C.   +5 more
europepmc   +1 more source

Upper Airway-Related Symptoms According to Mental Illness and Sleep Disorders among Workers Employed by a Large Non-Profit Organization in the Mountain West Region of the United States. [PDF]

Int J Environ Res Public Health, 2023
Merrill RM, Gibbons IS, Barker CJ.
europepmc   +1 more source

Examining The Impact Of Sarbanes-Oxley On Non-Profit Health Care Organizations

, 2012
Caprina P. Beal, Thomas E. Griffin
openalex   +2 more sources

Using creative problem solving (CPS) to improve leadership in a non-profit organization [PDF]

, 2013
Fernando Sousa, Paula Castelão, Ileana Pardal Monteiro, René Pellissier   +3 more
openalex   +1 more source