Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Doctors' job shifts between non-profit and for-profit healthcare organisations: evidence from a national panel of doctors. [PDF]
BMC Res NotesFadum EA +4 more
europepmc +1 more source
Bridging and Bonding: A Case for Prioritizing Social and Organizational Connectedness in Non-Profit Literacy Programming. [PDF]
Int J Community Wellbeing, 2023 Gosine K, Parker DC, Gallagher T.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Non-profit research: an insight into the management and monitoring of clinical trials in Italy. [PDF]
Glob Reg Health Technol AssessTizi F +5 more
europepmc +1 more source
Collaboration among psychological researchers, the government, and non-profit organizations for "Konkatsu" (marriage hunting) in Japan. [PDF]
Front Psychol, 2022 Nishimura T +6 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Sustaining non-profit organizations: Strategic, managerial and financial perspectives. [PDF]
PLoS OneHarb Y, Khabbaz L, Azouri M, Estephan S.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Orchestrating faster access to products of non-profit R&D: a case study of a novel regimen for drug-resistant tuberculosis. [PDF]
BMJ Glob HealthMoon S, Vieira MCF, Large K.
europepmc +1 more source