Results 91 to 100 of about 1,209,595 (304)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Special Economic Zones as a Factor in Ensuring Security of Social and Economic Development of the Territory

open access: yesУправленческое консультирование, 2018
This article analyzes the tools of special economic zones as a means of ensuring security of socio-economic development of the territory. Considered Canadian experience of regional development on the basis of special economic zones and project forms of ...
Ivan Nikolaevich Makarov   +2 more
doaj  

The Jurisprudence of Interests translated and edited by M. Magdalena Schoch [PDF]

open access: yes, 1948
The  purpose  of  this  report  is  to  examine  and  describe  how  an  elite  sports organization uses  implementation  of  values  to  strengthen  the  organizational culture and the strategy.
Sayre, Paul
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

WhiteDwarf.org - Establishing a permanent endowment for the Whole Earth Telescope [PDF]

open access: yes, 2002
White Dwarf Research Corporation is a 501(c)(3) non-profit organization dedicated to scientific research and public education on topics relevant to white dwarf stars.
Metcalfe, Travis S.
core   +3 more sources

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