Results 21 to 30 of about 21,652 (222)

A Study to Determine the Association between Monocyte to HDL Cholesterol Ratio, Neutrophil to Lymphocyte Ratio, Red Blood Cell Distribution Width (RDW), and Diabetic Retinopathy in a Tertiary Care Hospital in Eastern India [PDF]

Bengal Physician Journal
Background: Diabetic retinopathy is an important microvascular complication of diabetes mellitus (DM) leading to visual impairment. Inflammation of retinal vasculature plays a pivotal role in its pathogenesis.
Rupak Chatterjee, Arindam Naskar, Tania Ray Bhadra, Kingshuk Jana, Shambo Samrat Samajdar, Shatavisa Mukherjee   +5 more
doaj   +1 more source

Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy.

PLoS ONE, 2023
BackgroundDiabetic retinopathy is a frequent complication of diabetes mellitus and a leading cause of blindness in adults. The objective of this study was to elucidate the diabetic retinopathy pathophysiology in more detail by comparing protein ...
Teresa Tsai, Mohannad Alwees, Mohammad Ali Asaad, Janine Theile, Vinodh Kakkassery, H Burkhard Dick, Tim Schultz, Stephanie C Joachim   +7 more
doaj   +1 more source

Prevalence of ocular findings and their association with glycemia in dogs with diabetes mellitus: A 10-year clinical study (2009-2019)

Open Veterinary Journal, 2023
Background: Although ocular findings in diabetic patients are well described, prevalence data for those is unknown. Aim: To describe the prevalence of ocular findings and their association with glycemia in dogs with diabetes mellitus.
Francisco Cantero, Ángel Ortilles, M. Teresa-Peña, Marta Leiva   +3 more
doaj   +1 more source

Demographics, Awareness and Pattern of Diabetic Retinopathy among Diabetic Patients

Journal of Nobel Medical College
Background: Diabetic retinopathy is one of the emerging causes of blindness in developing countries. This study was carried out among diabetic patients to determine the demographics, severity of diabetic retinopathy and also to assess the level of ...
Anjila Basnet, Raghunandan Byanju, Samir Thapa, Sanjit Kumar Shah, Suman Simkhada   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association of serum vitamin D and parathormone levels in patients of type 2 diabetes mellitus with diabetic retinopathy

Bangabandhu Sheikh Mujib Medical University Journal, 2017
The present study was aimed to evaluate the association of serum 25-hydroxy vitamin D and parathormone in 46 patients of type 2 diabetes mellitus with diabetic retinopathy [non-proliferative, (n=27); proliferative (n=19)].
Mohammad Shiblee Zaman, Md. Matiur Rahman, Subrata Kumar Biswas, Md. Mozammel Hoque, Khondakar Alwan Nahid   +4 more
doaj   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Frequency of Diabetic Retinopathy in Karachi, Pakistan: A Hospital Based Study

Journal of the Dow University of Health Sciences, 2015
Objective: This study was conducted to determine the prevalence of diabetic retinopathy in diabetes patients presenting to the National Institute of Diabetes and Eye out patient department of Dow University Hospital (Ohja campus), Dow University of ...
saba Alkhairy, Abdul Rasheed, Farnaz Aziz, Mazhar ul Hassan, Sarfaraz Nawaz   +4 more
doaj   +4 more sources

Automatic non-proliferative diabetic retinopathy screening system based on color fundus image

BioMedical Engineering OnLine, 2017
Background Non-proliferative diabetic retinopathy is the early stage of diabetic retinopathy. Automatic detection of non-proliferative diabetic retinopathy is significant for clinical diagnosis, early screening and course progression of patients. Methods
Zhitao Xiao, Xinpeng Zhang, Lei Geng, Fang Zhang, Jun Wu, Jun Tong, Philip O. Ogunbona, Chunyan Shan   +7 more
doaj   +1 more source