Results 91 to 100 of about 62,096,225 (258)

Technical aspects of neuraxial analgesia during labor and maternity care: an updated overview

Journal of Anesthesia, Analgesia and Critical Care
Labor analgesia is increasingly widespread throughout the world with a rate ranging from 10 to 60%. The benefits regarding clinical and non-clinical maternal–fetal outcomes are currently discussed in international scientific literature.
Antonio Coviello, Carmine Iacovazzo, Maria Grazia Frigo, Marilena Ianniello, Dario Cirillo, Giuseppe Tierno, Andrea Uriel de Siena, Pasquale Buonanno, Giuseppe Servillo   +8 more
doaj   +1 more source

Management of pain in individuals with spinal cord injury: Guideline of the German-Speaking Medical Society for Spinal Cord Injury

GMS German Medical Science, 2019
Introduction: Pain is a prominent complication in spinal cord injury (SCI). It can either occur as a direct or as an indirect consequence of SCI and it often heavily influences the quality of life of affected individuals.
Franz, Steffen, Schulz, Barbara, Wang, Haili, Gottschalk, Sabine, Grüter, Florian, Friedrich, Jochen, Glaesener, Jean-Jacques, Bock, Fritjof, Schott, Cordelia, Müller, Rachel, Schultes, Kevin, Landmann, Gunther, Gerner, Hans Jürgen, Dietz, Volker, Treede, Rolf-Detlef, Weidner, Norbert   +15 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Sub-analysis of both studies with randomized controlled trials and non-randomized controlled.

Sub-analysis of both studies with randomized controlled trials and non-randomized controlled.
Lailiang Wang (18397297), Qun Luo (600767), Fangfang Zhou (4167628), Yixin Chen (64217), Shuzhen Zhang (761642)   +4 more
core   +1 more source

Methodological progress note: Pilot randomized controlled trials [PDF]

Definitive randomized controlled trials (RCTs) are the cornerstone of evidence-based medicine but can be complicated, protracted, and expensive. Given the challenges of large-scale trials, pilot trials serve as a crucial initial step, allowing for ...
Marsh, Nicole, Keogh, Samantha, Corley, Amanda   +2 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Functional Relaxation and Guided Imagery as Complementary Therapy in Asthma: A Randomized Controlled Clinical Trial [PDF]

, 2009
Background: Asthma is a frequently disabling and almost invariably distressing disease that has a high overall prevalence. Although relaxation techniques and hypnotherapeutic interventions have proven their effectiveness in numerous trials, relaxation ...
N. Sauer, F. Röhricht, D. Nowak, Loew, T., C. Lahmann, T. Schuster, Sauer, N., Nowak, Dennis, K. Tritt, M. Nickel, T. Loew, Ronel, J., M. Noll-Hussong, Schuster, T., Tritt, K., Noll-Hussong, M., J. Ronel, Lahmann, Claas, Lahmann, C., Röhricht, F., Nickel, M., Nowak, D., Lahmann, C.;Nickel, M.;Schuster, T.;Sauer, N.;Ronel, J.;Noll-Hussong, M.;Tritt, K.;Nowak, D.;Röhricht, F.;Loew, T., Lahmann, C;Nickel, M;Schuster, T;Sauer, N;Ronel, J;Noll-Hussong, M;Tritt, K;Nowak, D;Rohricht, F;Loew, T   +23 more
core   +1 more source

Vitamin D in patients with Hashimoto's disease: a systematic review and meta-analysis

Revista de Ciências Farmacêuticas Básica e Aplicada, 2021
One of the most common thyroid dysfunctions is Hashimoto's disease (HD), characterized by the production of specific antibodies against thyroid gland antigens (Anti-Tg and Anti-TPO).
Josiane Marlei Muller Fernandes dos Santos, Erika Vaz Alencar, Elisa Caroline de Oliveira Martins, Cíntia Aparecida Ossoski, Aline de Fátima Bonetti   +4 more
doaj  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Vitamin D supplementation and breast cancer prevention : a systematic review and meta-analysis of randomized clinical trials [PDF]

, 2013
In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis ...
Nancy Santesso (435397), Pizzuti, Laura, Pizzuti, L, Montella, Maurizio, Nancy Santesso, Santesso Nancy, Patrizia Vici (85361), Santesso, Nancy, Barba, Maddalena, Anna Crispo (435403), Mariani, Luciano, Barba M., Maugeri-Saccà, Marcello, Maddalena Barba, Montella Maurizio, Laura Pizzuti, Mottolese Marcella, Sergi D., Patrizia Vici, Domenico Sergi, Francesca Sperati, Stranges, Saverio, Luigi Di Lauro (435401), Vici Patrizia, Luciano Mariani (435398), Antonio Giordano, Barba Maddalena, Montella, M, Marcella Mottolese (85368), Sperati, Francesca, Francesca Sperati (95245), Mottolese M., Sperati Francesca, Saverio Stranges, Mariani L., Crispo, A, Di Lauro, L, Laura Pizzuti (435400), Pizzuti L., Saverio Stranges (73786), Marcella Mottolese, Giordano, A, Pizzuti Laura, Crispo A., Marcello Maugeri-Saccà, Barba, M, Maugeri-Saccà Marcello, Stranges, S, Santesso N., Di Lauro, Luigi, Stranges S., Maurizio Montella, Marcello Maugeri-Saccà (435396), Antonio Giordano (55096), Vici P., Sperati, F, Di Lauro Luigi, Sergi, D, Sergi, Domenico, Santesso, N, Mariani, L, Luigi Di Lauro, Giordano, Antonio, MD, Giordano A., Mottolese, M, Giordano, Antonio|, Stranges Saverio, Di Lauro L., Mottolese, Marcella, Maddalena Barba (82927), Sergi Domenico, Crispo Anna, Luciano Mariani, Maurizio Montella (435402), Sperati F., Giordano Antonio, Vici, P, Montella M., Crispo, Anna, Maugeri-Saccà, M, Vici, Patrizia, Mariani Luciano, Anna Crispo, Domenico Sergi (435399), Maugeri-Sacca M.   +84 more
core   +1 more source