Results 81 to 90 of about 62,096,225 (258)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Primary care practice-based care management for chronically ill patients (PraCMan): study protocol for a cluster randomized controlled trial [ISRCTN56104508] [PDF]

, 2011
Background: Care management programmes are an effective approach to care for high risk patients with complex care needs resulting from multiple co-occurring medical and non-medical conditions.
Baldauf Annika, Gerlach, Ferdinand M., Joachim Szecsenyi, Beyer Martin, Szecsenyi, Joachim, Gerlach Ferdinand M, Peters-Klimm Frank, Ferdinand M Gerlach, Peters-Klimm, Frank, Erler, Antje, Cornelia Mahler, Rochon Justine, Gensichen Jochen, Mahler Cornelia, Freund, Tobias, Martin Beyer, Antje Erler, Szecsenyi Joachim, Gensichen, Jochen, Freund Tobias, Beyer, Martin, Justine Rochon, Mahler, Cornelia, Baldauf, Annika, Tobias Freund, Frank Peters-Klimm, Jochen Gensichen, Rochon, Justine, Erler Antje, Annika Baldauf   +29 more
core   +2 more sources

Glucagon-like Peptide-1 Receptor Agonists: A New Frontier in Treating Alcohol Use Disorder

Brain Sciences
Background/Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which were originally developed for managing type 2 diabetes by enhancing insulin secretion and reducing appetite, have emerged as promising candidates in alcohol use disorder ...
Tyler S. Oesterle, Ming-Fen Ho
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The challenges faced in the design, conduct and analysis of surgical randomised controlled trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the
Jonathan A Cook, Cook, Jonathan Alistair, Cook Jonathan A   +2 more
core   +2 more sources

Clinical research on homeopathic preparations: protocol template for a series of systematic reviews

Systematic Reviews
Background The clinical benefits of homeopathic preparations (HPs) used in anthroposophic medicine and homeopathy remain a topic of debate. Systematic reviews (SRs), with or without meta-analyses (MAs), that assess the literature in line with scientific ...
Martin Loef, Robbert van Haselen, Stephan Baumgartner   +2 more
doaj   +1 more source

Novel Approaches of Indocyanine Green and aPDT in the Treatment of Periodontitis: A Narrative Review

Surgeries
In recent years, increasing attention has been given to adjunctive therapies aimed at improving clinical outcomes in periodontal treatment. Among these, antimicrobial photodynamic therapy (aPDT) using the photosensitizer indocyanine green (ICG) has shown
Raimonda Šilė, Vita Mačiulskienė-Visockienė, Renata Šadzevičienė, Ingrida Marija Pacauskienė   +3 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Randomized controlled trials in pediatric surgery: could we do better?

, 2003
BACKGROUND/PURPOSE: Randomized controlled trials (RCTs) are accepted as the gold standard for assessing the effectiveness of clinical interventions but are rarely reported in pediatric surgery. Have RCTs submitted to the British Association of Paediatric
Stringer, Mark D, Curry, Joe I, Reeves, Barnaby   +2 more
core   +1 more source

Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials [PDF]

, 2010
Background: We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma.Methods: Randomized controlled ...
Gill Levitt, Smith Lesley A, Cornelius Victoria R, Canney Peter, Levitt, G, Smith, Lesley A., Canney, P, Verrill, Mark, Lesley A Smith, Cornelius, Victoria, Verrill Mark, Plummer, CJ, Verrill, M, Peter Canney, Cornelius, VR, Lesley, A. Smith, Canney, Peter, Plummer, Christopher J., Victoria R Cornelius, Plummer Christopher J, Alison Jones, Smith, LA, Christopher J Plummer, Jones, Alison, Jones Alison, Jones, A, Levitt Gill, Levitt, Gill, Cornelius, Victoria R., Mark Verrill   +29 more
core   +2 more sources