Results 61 to 70 of about 62,096,225 (258)
The effectiveness of alcohol screening and brief intervention in emergency departments: A multicentre pragmatic cluster randomized controlled trial [PDF]
, 2014 Background
Alcohol misuse is common in people attending emergency departments (EDs) and there is some evidence of efficacy of alcohol screening and brief interventions (SBI).Patton, Robert, Dale, V, Eileen Kaner (588847), Deluca Paolo, Drummond, Colin, Gilvarry Eilish, Eilish Gilvarry (588836), Newbury-Birch, Dorothy, Touquet Robin, Judy Myles (588839), Martin Bland (222260), Colin Drummond (339336), Mike Crawford, Cassidy, P, Deluca, Paolo; id_orcid, Patton, R, Bland, Martin, Shepherd Jonathan, Newbury-Birch Dorothy, Eileen Kaner, Adenekan Oyefeso, Myles Judy, Steve Parrott, Heather, Nick, Oyefeso, Adenekan, Parrott, Steve, Colin Drummond, Ruth McGovern, Katherine Perryman, Coulton, S, Patton Robert, Nick Heather (588837), Perryman, K, Paolo Deluca, Steve Parrott (588841), Dorothy Newbury-Birch (588840), Dale, Veronica, Myles, J, Cassidy, Paul, Tom Phillips, Godfrey Christine, Kaner, E, Newbury-Birch, D, Oyefeso, A, Cassidy Paul, Simon Coulton, Robin Touquet (588846), Drummond Colin, Heather Nick, Veronica Dale (588835), Jonathan Shepherd (588845), McGovern Ruth, Oyfeso, Adenekan, Touquet, R, Perryman Katherine, Shepherd, Jonathan, Parrott, S, Phillips, T, Veronica Dale, Paolo Deluca (588833), Christine Godfrey (227956), Paul Cassidy (588834), Ruth McGovern (588838), Adenekan Oyefeso (18454), Godfrey, Christine, Myles, Judy, Jonathan Shepherd, Robin Touquet, Parrott Steve, Christine Godfrey, Perryman, Katherine, Phillips, Tom, Oyefeso Adenekan, Katherine Perryman (588843), Tom Phillips (588844), Judy Myles, Drummond, C, Heather, N, Deluca, Paolo, Coulton, Simon, Coulton Simon, Kaner Eileen, Simon Coulton (167071), Newbury-Birch, Dorothy; id_orcid, Drummond, Colin; id_orcid, Nick Heather, Phillips Tom, Crawford, M, Dorothy Newbury-Birch, Mike Crawford (282626), Bland Martin, Crawford Mike, Dale Veronica, Touquet, Robin, Gilvarry, Eilish, Kaner, Eileen, Robert Patton (588842), McGovern, Ruth, McGovern, R, Patton, Bob, Martin Bland, Crawford, Mike, Torquet, Robin, Robert Patton, Shepherd, J, Philips, Tom, Gilvarry, E, Eilish Gilvarry, Deluca, P, Godfrey, C, Paul Cassidy, Bland, M +111 morecore +1 more sourceEffects of Drug Administration on Postoperative Pain in Orthognathic Surgery: A Systematic Review
Clinical and Experimental Dental ResearchObjectives This systematic review aims to offer indications on how drug administration affects postoperative pain in patients undergoing orthognathic surgery.Gianna Dipalma, Angelo Michele Inchingolo, Lilla Riccaldo, Roberta Morolla, Pietro Lauria, Roberto Vito Giorgio, Valeria Colonna, Benito F. P. Pennacchio, Antonio Mancini, Andrea Palermo, Alessio Danilo Inchingolo, Francesco Inchingolo +11 moredoaj +1 more sourceArtificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...Leonardo Andreoni, Alberto Crediwiley +1 more sourceVitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. [PDF]
, 2012 Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess ...Salovaara, K., Smith, H.E., Jackson, Rebecca D, Sanders, Kerrie M., Rebecca D Jackson (16135031), Tahir Masud (804313), Jacobs, E.T., JoAnn E Manson (13567339), Robbins, John A., Haakon E Meyer (10282121), Rejnmark, Lars, Abrahamsen, Bo, Jackson, Rebecca D., Mosekilde, Leif, Brixen, K., Mosekilde, L., Cyrus Cooper (141250), Lars Rejnmark (3752971), Elizabeth T Jacobs (16135028), Bo Abrahamsen (650396), Meyer, Haakon E., Alison Avenell (82040), Jacobs, Elizabeth T., Smith, Helen E, Abrahamsen, Bo; id_orcid, Salovaara, Kari, Manson, Joann E, Torgerson, D., Robbins, J.A., Robbins, John A, Francis, Roger M., Roger M Francis (7380278), Jacobs, Elizabeth T, Manson, JoAnn E., Anderson, F., Francis, R.M., Kerrie M Sanders (13488952), David Torgerson (462403), Masud, T., Helen E Smith (16045475), Abrahamsen, B., Manson, J.E., Cooper, Cyrus, Sanders, K.M., Frazer Anderson (16135022), Meyer, Haakon E, Kari Salovaara (16135025), Meyer, H.E., Francis, Roger M, John A Robbins (8553495), Torgerson, David, Masud, Tahir, Anderson, Frazer, Cooper, C., Kim Brixen (16135034), Jackson, R.D., Smith, Helen E., Rejnmark, L., Avenell, Alison, Avenell, A., Brixen, Kim, Leif Mosekilde (349340), Sanders, Kerrie M +62 morecore +1 more sourceA context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos +9 morewiley +1 more sourceMinimally invasive versus open pancreatoduodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): study protocol for an international multicenter patient-blinded randomized controlled trial
Trials, 2023 Background Minimally invasive pancreatoduodenectomy (MIPD) aims to reduce the negative impact of surgery as compared to open pancreatoduodenectomy (OPD) and is increasingly becoming part of clinical practice for selected patients worldwide.Nine de Graaf, Anouk M. L. H. Emmen, Marco Ramera, Bergthor Björnsson, Ugo Boggi, Caro L. Bruna, Olivier R. Busch, Freek Daams, Giovanni Ferrari, Sebastiaan Festen, Jony van Hilst, Mathieu D’Hondt, Benedetto Ielpo, Tobias Keck, Igor E. Khatkov, Bas Groot Koerkamp, Daan J. Lips, Misha D. P. Luyer, J. Sven D. Mieog, Luca Morelli, I. Quintus Molenaar, Hjalmar C. van Santvoort, Mirjam A. G. Sprangers, Clarissa Ferrari, Johannes Berkhof, Patrick Maisonneuve, Mohammad Abu Hilal, Marc G. Besselink, for the European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS) +28 moredoaj +1 more sourceNeutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang +8 morewiley +1 more sourceProcess evaluation in randomised controlled trials of complex interventions. [PDF]
, 2006 Most randomised controlled trials focus on outcomes, not on the processes involved in implementing an intervention. Using an example from school based health promotion, this paper argues that including a process evaluation would improve the science of ...Allen, Elizabeth, Strange, V, Bonell, Chris, Bonell, C, Stephenson, J, Oakley, A, RIPPLE Study Team, Stephenson, Judith, Allen, E, Oakley, Ann, Strange, Vicki +10 morecore +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more source
