Results 241 to 250 of about 19,922,741 (302)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Defining and Predicting HIV Immunological Non-Response: A Multi-Definition Analysis from an Indonesian Cohort. [PDF]

Viruses
Rachman BE, Supranoto YTN, Iskandar SI, Asmarawati TP, Khairunisa SQ, Arfijanto MV, Hadi U, Miftahussurur M, Nasronudin N, Kameoka M, Rahayu RP, Hidayati AN.   +11 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Serum or Plasma Oncostatin M for Predicting Primary Non-Response to Tumor Necrosis Factor-α Antagonist Therapy in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. [PDF]

Clin Pract
Barffour MA, Karanja E, Gandhi M, Kais SS, Kapur S, Ghouri YA.   +5 more
europepmc   +1 more source

Immune non-response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches. [PDF]

HIV Med
Silvestre C, Gross A, Makinson A.
europepmc   +1 more source

Recruitment Strategies, Response Rates, and Non-Response Patterns in a Nationwide Registry-Based PRO Survey of Cancer Survivors and the General Population: The SURV-ICE Cohort. [PDF]

Cancers (Basel)
Sigurðardóttir K, Friðriksdóttir N, Kristinsdóttir NM, Kristjánsdóttir L, Skúlason HG, Haraldsdóttir Á, Alfonsdóttir SÁ, Jóhannesdóttir AKB, Birgisson H, Tryggvadóttir H, Birgisdóttir F, Valdimarsdóttir H, Aspelund T, van de Poll-Franse L, Gunnarsdóttir S.   +14 more
europepmc   +1 more source

Negative health outcomes of non-response to the Kihon checklist in community-dwelling older people: a 19-month prospective cohort study. [PDF]

BMC Geriatr
Kazawa K, Moriyama M, Sato K, Ishii S.
europepmc   +1 more source

Non-Response to Obeticholic Acid Is Associated With Heightened Risks of Developing Clinical Events in Primary Biliary Cholangitis. [PDF]

Aliment Pharmacol Ther
Abbas N, Smith R, Lytvyak E, Scaravaglio M, Halliday N, Almahroos A, Eden N, Lloyd-Madden D, Sharma S, Ferguson J, Dyson JK, Thorburn D, Jones D, Montano-Loza AJ, Carbone M, Invernizzi P, Mells G, Culver EL, Trivedi PJ.   +18 more
europepmc   +1 more source

Efficacy of Biologics in Patients with Ulcerative Colitis Exhibiting Non-Response or Insufficient Response to Cytapheresis. [PDF]

J Clin Med
Iizuka M, Etou T, Yorozu H, Kato B, Edagawa T, Sagara S, Matsushita HO, Yoshikawa K.   +7 more
europepmc   +1 more source