Results 101 to 110 of about 10,270,570 (295)

THE STATUS OF APPOSITION STRUCTURES IN THE MODERN GERMAN LANGUAGE

open access: yesВестник Кемеровского государственного университета, 2018
The research features the structures interpreted by many modern linguists as apposition. The spectrum of such structures is wide and varied. The identification of the relevant attributes of the category of apposition in the modern German language makes ...
S. V. Muratova
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

State abortion restrictiveness and prevalence of intimate partner violence and domestic violence among recently birthing black and white individuals

open access: yesFrontiers in Reproductive Health
ObjectivesIntimate partner violence (IPV) and non-intimate domestic violence (DV) during pregnancy may result in poor maternal and infant health outcomes.
Katherine Neff   +29 more
doaj   +1 more source

The "Fame Effect" or How the syntactic choices of writers can be explained by their assumptions about their addressees' state of knowledge: the case of relevance-oriented, non-restrictive noun modifiers

open access: yesDiscours, 2010
In this paper we would like to explore, within Vallduví’s (1992, 1993) information packaging theory, how writers’ assumptions about their addressees’ state of knowledge can account for the choice writers make between competing syntactic structures, which
Rudy Loock
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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