Results 121 to 130 of about 10,270,570 (295)

The ADR Loophole to Restrictive Non-Compete Agreements [PDF]

, 2019
This Comment considers a key question: do employers have a strategy to protect themselves if these restrictive states are restricting corporations from protecting their self-developed trade secrets?
Itani, Jad
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Restrictive filling pattern of transmitral inflow in acute decompensated heart failure with preserved ejection fraction: insights from the KCHF registry

Open Heart
Background The restrictive filling pattern of transmitral inflow has been shown to be associated with a poor prognosis in patients with heart failure (HF) with reduced ejection fraction or myocardial infarction.
Takeshi Kitai, Yutaka Furukawa, Kenji Ando, Yuichi Kawase, Kazuya Nagao, Takao Kato, Yasutaka Inuzuka, Takeshi Kimura, Koichiro Kuwahara, Hidenori Yaku, Yodo Tamaki, Neiko Ozasa, Erika Yamamoto, Yusuke Yoshikawa, Yukihito Sato, Koh Ono, Moritake Iguchi, Takashi Morinaga, Yutaro Miyoshi   +18 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Restrictive Cardiomyopathy

, 2021
Restrictive cardiomyopathy (RCM) is distinguished by diastolic dysfunction in a non-dilated ventricle. Multiple types of restrictive cardiomyopathies vary according to pathogenesis, clinical presentation, diagnostic evaluation, treatment, and prognosis ...
Brown, Kristen N, Diaz, Rene R, Pendela, Venkata Satish   +2 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Restrictive and Non Restrictive Relative Clauses in Modern Standard Arabic: An Experimental Study

, 2019
The aim of this paper is to present a systematic syntactic comparison betweern restrictive and non restrictive relative clauses in Modern Standard Arabic, providing evidence for their different structural properties and, consequently, for the necessity ...
Frascarelli, Mara, LACROCE, ALESSIA
core  

A hinge-free, non-restrictive, lightweight tethered exosuit for knee extension assistance during walking. [PDF]

IEEE Trans Med Robot Bionics, 2020
Park EJ, Akbas T, Eckert-Erdheim A, Sloot LH, Nuckols RW, Orzel D, Schumm L, Ellis TD, Awad LN, Walsh CJ.   +9 more
europepmc   +1 more source