Results 101 to 110 of about 1,190,584 (342)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction

Tumor Biology, 2017
Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a ...
Yimin Lu, Jun Wang, Lei Liu, Lequn Yu, Nian Zhao, Xingju Zhou, Xudong Lu   +6 more
doaj   +1 more source

Tissue-Plasma TMB Comparison and Plasma TMB Monitoring in Patients With Metastatic Non-small Cell Lung Cancer Receiving Immune Checkpoint Inhibitors [PDF]

, 2020
Alex Friedlaender, Thierry Nouspikel, Yann Christinat, Liza Ho, Thomas McKee, Alfredo Addeo   +5 more
openalex   +1 more source

Characteristics and Treatment Outcomes in Advanced-Stage Non-Small Cell Lung Cancer Patients with a KRAS G12C Mutation: A Real-World Study [PDF]

, 2022
Oliver Illini, Hannah Fabikan, Maximilian J. Hochmair, Christoph Weinlinger, Dagmar Krenbek, Luka Brčić, Ulrike Setinek, Angelika Terbuch, Gudrun Absenger, Selma Konjić, Arschang Valipour   +10 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18 [PDF]

, 2014
Keng Zhong, Kun Chen, Lin Han, Bailing Li   +3 more
openalex   +1 more source

Non–Small Cell Lung Cancer [PDF]

Journal of the National Comprehensive Cancer Network, 2010
David S, Ettinger, Wallace, Akerley, Gerold, Bepler, Matthew G, Blum, Andrew, Chang, Richard T, Cheney, Lucian R, Chirieac, Thomas A, D'Amico, Todd L, Demmy, Apar Kishor P, Ganti, Ramaswamy, Govindan, Frederic W, Grannis, Thierry, Jahan, Mohammad, Jahanzeb, David H, Johnson, Anne, Kessinger, Ritsuko, Komaki, Feng-Ming, Kong, Mark G, Kris, Lee M, Krug, Quynh-Thu, Le, Inga T, Lennes, Renato, Martins, Janis, O'Malley, Raymond U, Osarogiagbon, Gregory A, Otterson, Jyoti D, Patel, Katherine M, Pisters, Karen, Reckamp, Gregory J, Riely, Eric, Rohren, George R, Simon, Scott J, Swanson, Douglas E, Wood, Stephen C, Yang   +34 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

LncRNA MIR503HG Inhibits Non-Small Cell Lung Cancer Cell Proliferation by Inducing Cell Cycle Arrest Through the Downregulation of Cyclin D1

Cancer Management and Research, 2020
Shufen Xu,* Shengping Zhai,* Tiantian Du,* Zhan Li Respiratory Department, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai City, Shandong Province 264000, People’s Republic of China*These authors contributed equally to this ...
Xu S, Zhai S, Du T, Li Z
doaj  

Comparison of Epidermal Growth Factor Receptor Mutation Statuses in Tissue and Plasma in Stage I–IV Non-Small Cell Lung Cancer Patients [PDF]

, 2012
Xiao Zhao, Rubing Han, Jing Zhao, Jun Wang, Fan Yang, Wei Zhong, Li Zhang, Longyun Li, Mengzhao Wang   +8 more
openalex   +1 more source