Results 71 to 80 of about 1,190,584 (342)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Archives of Basic and Clinical ResearchObjective: We aimed to investigate to usability and feasibility of perfusion computerized tomography (PCT) in differentiating small cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC).
Ömer Özyiğit, Suat Eren
doaj +1 more source
Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe [PDF]
, 2001 Background: Since the incidence of the histological subtypes of lung cancer in industrialised countries has changed dramatically over the last two decades, we reviewed trends in the incidence and prognosis in North America, Australia, New Zealand and ...
Coebergh, J.W.W. (Jan Willem) +1 more
core +3 more sources
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Chemotherapy for advanced non-small-cell lung cancer: Role of paclitaxel and gemcitabine [PDF]
, 1999 Objective. To review the role of chemotherapy in advanced non-small-cell lung cancer, focusing on cisplatin-based regimens and two new drugs: paclitaxel and gemcitabine. Data sources. Medline search of the relevant English literature.
Ip, MSM, Lam, WK, Tsang, KWT
core
Regression of murine lung tumors by the let-7 microRNA. [PDF]
, 2010 MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer.
Bader, AG +10 more
core +2 more sources
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Maintenance therapies for non small cell lung cancer
Frontiers in Oncology, 2014 Treatment of lung cancer had evolved during the last decade with the introduction of new chemotherapeutic regimens and targeted therapies. However, the maximum benefit reached after first line therapy is limited by the cumulative toxicity of platinum ...
Normand eBlais, Elie eKassouf
doaj +1 more source
Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer [PDF]
, 2014 BACKGROUND: Lung cancer is one of the leading causes of cancer death worldwide. Even with complete resection, the prognosis of early-stage non-small cell lung cancer is poor due to local and distant recurrence, and it remains unclear which biomarkers are
Hideki Ishihara +8 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source