Results 41 to 50 of about 76,322 (245)

An efficient primal dual prox method for non-smooth optimization [PDF]

Machine Learning, 2014
We study the non-smooth optimization problems in machine learning, where both the loss function and the regularizer are non-smooth functions. Previous studies on efficient empirical loss minimization assume either a smooth loss function or a strongly convex regularizer, making them unsuitable for non-smooth optimization.
Yang, Tianbao, Mahdavi, Mehrdad, Jin, Rong, Zhu, Shenghuo   +3 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Incremental Weak Subgradient Methods for Non-Smooth Non-Convex Optimization Problems

Information
Non-smooth, non-convex optimization problems frequently arise in modern machine learning applications, yet solving them efficiently remains a challenge.
Narges Araboljadidi, Valentina De Simone
doaj   +1 more source

Understanding Notions of Stationarity in Non-Smooth Optimization

, 2020
Accepted for publication in IEEE Signal Processing Magazine ...
Li, Jiajin, So, Anthony Man-Cho, Ma, Wing-Kin   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Stochastic approximation algorithms for support vector machines semi-supervised binary classification

Lietuvos Matematikos Rinkinys, 2008
In this paper,we consider the problem of semi-supervisedbinary classificationby Support Vector Machines (SVM). This problem is explored as an unconstrained and non-smooth optimization task when part of the available data is unlabelled.
Vaida Bartkutė-Norkūnienė
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Observability and Controllability Analysis for Sandwich Systems with Backlash

International Journal of Applied Mathematics and Computer Science, 2015
In this paper, an approach to analyze the observability and controllability of sandwich systems with backlash is proposed. In this method, a non-smooth state-space function is used to describe the sandwich systems with backlash which are also non-smooth ...
Luo Na, Tan Yonghong, Dong Ruili
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Non-Smooth Multi-Objective Controller Synthesis for Test-Mass Actuation in Gravitational-Wave Detectors

Galaxies
This paper proposes a non-smooth controller optimization method and shows the results of ongoing research on the implementation of this method for gravitational-wave applications.
Sander K. Sijtsma, Pooya Saffarieh, Nathan A. Holland, Sil T. Spanjer, Wouter B. J. Hakvoort, Conor M. Mow-Lowry   +5 more
doaj   +1 more source