Results 51 to 60 of about 54,158 (261)

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Novel Insights Into the Effects of Interleukin 6 Antagonism in Non–ST‐Segment–Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non–ST‐segment–elevation myocardial infarction trial, the first randomized trial of ...
Marc J. George, Ola Kleveland, Jorge Garcia‐Hernandez, Jutta Palmen, Ruth Lovering, Rune Wiseth, Pål Aukrust, Jorgen Engmann, Jan Kristian Damås, Aroon D. Hingorani, Lars Gullestad, Juan P. Casas, Thor Ueland   +12 more
doaj   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

AI &Innovation, EarlyView.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury, Kandarpa Kumar Sarma, Lachit Dutta   +2 more
wiley   +1 more source

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, Accepted Article.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week (W), double‐blind, placebo‐controlled, phase 3 POETYK PsA‐2 study
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

Platelet FcɣRIIa Expression Refines Clinical Risk Assessment After Myocardial Infarction

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background In patients with myocardial infarction (MI), quantifying expression of platelet FcɣRIIa (pFCG) stratifies risk of subsequent MI, stroke, and death. Aims Assess the prognostic implications of clinical risk alone and in combination with the pFCG test.
David J. Schneider, Sean R. McMahon, Dominick J. Angiolillo, Alexander C. Fanaroff, Homam Ibrahim, Patrick K. Hohl, Brett L. Wanamaker, Mark B. Effron, Peter M. DiBattiste, behalf of the investigators   +9 more
wiley   +1 more source

Magnetocardiography in diagnosis of MINOCA: a case series

Frontiers in Cardiovascular Medicine
BackgroundCurrently, there is a paucity of accurate, convenient, rapid, and efficient diagnostic approaches for myocardial infarction with non-obstructive coronary arteries (MINOCA) in patients who have undergone coronary angiography (CAG) or coronary ...
Xiaoyan Xue, Xiaoyan Xue, Xiaoyan Xue, Xiaoyan Xue, Jiandong Zhang, Yuheng Zhou, Yuheng Zhou, Yuheng Zhou, Yuheng Zhou, Yihao Zhu, Yihao Zhu, Yihao Zhu, Yihao Zhu, Jiaqi Liang, Jiaqi Liang, Jiaqi Liang, Jiaqi Liang, Kangqi Tian, Kangqi Tian, Kangqi Tian, Kangqi Tian, Dong Xu, Yuguo Chen, Yuguo Chen, Yuguo Chen, Yuguo Chen, Xu Zhang, Xu Zhang, Xu Zhang, Xu Zhang, Xu Zhang, Xu Zhang, Min Xiang, Min Xiang, Min Xiang, Min Xiang, Min Xiang, Min Xiang   +37 more
doaj   +1 more source

Lower AKI Risk and Higher Survival With Microaxial Flow Pump Support During Elective PCI: A Propensity Score‐Matched Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Acute kidney injury (AKI) is associated with worse outcomes after percutaneous coronary intervention (PCI). Previous, smaller studies suggested nephroprotective effects of micro‐axial flow pump (mAFP) during PCI. This study aimed to compare renal outcomes of high‐risk PCI with mAFP or intraaortic balloon pump (IABP) support.
Elric Zweck, Andrew Shaw, Amin Polzin, Nudrat Noor, Sathya Unudurthi, Michael Cuchiara, Kai M. Schmidt‐Ott, Malte Kelm, Ralf Westenfeld, Rafael Kramann, Ravindra L. Mehta   +10 more
wiley   +1 more source

Prevalence and Clinical Correlates of TIMI Flow Grade Zero Culprit-artery Occlusion in Patients with NSTEMI Undergoing Early Percutaneous Coronary Intervention [PDF]

Al-Anbar Medical Journal
Background: A substantial proportion of patients with non-ST-elevation myocardial infarction (NSTEMI) have an acutely occluded culprit artery despite the absence of diagnostic ST-segment elevation on the presenting electrocardiogram.Objective: To ...
Raad Najim, Mufeed Taha
doaj   +1 more source

Non-ST segment elevation myocardial infarction in a patient with COVID-19

Heart Views, 2020
Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of cardiovascular (CV) manifestations. Primary cardiac manifestations of COVID-19 disease include acute coronary syndrome (ACS), myocarditis, and arrhythmias. Secondary cardiac involvement is usually due to a systemic inflammatory syndrome and can manifest as acute myocardial injury/
Fahmi Othman, Abdul Rehman Abid, Mohammad Alibrahim, Sabir Abdulkarim, Mohammed A Abdelaty, Mohamed Aboukamar, Salah Arafah   +6 more
openaire   +3 more sources

Mechanical Thrombus Aspiration for a Young STEMI Patient With Plaque Erosion: Time for a Stent‐Free Approach?

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT A 34‐year‐old man with no cardiovascular history presented with anterior ST‐elevation myocardial infarction and a large thrombotic occlusion of the mid left anterior descending artery. Following potent antithrombotic therapy and mechanical thrombus aspiration, angiography revealed vessel patency without residual significant stenosis, allowing ...
Domenico Simone Castiello, Francesco Greco, Antonio Curcio, Alberto Polimeni   +3 more
wiley   +1 more source