Results 51 to 60 of about 12,832,564 (302)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Several studies have suggested sex‐related differences in diagnostic and invasive therapeutic coronary procedures. Methods and Results Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German ...
Tobias Heer, Matthias Hochadel, Karin Schmidt, Julinda Mehilli, Ralf Zahn, Karl‐Heinz Kuck, Christian Hamm, Michael Böhm, Georg Ertl, Hans Martin Hoffmeister, Stefan Sack, Jochen Senges, Steffen Massberg, Anselm K. Gitt, Uwe Zeymer   +14 more
doaj   +1 more source

The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004 [PDF]

, 2006
Aims Our study aimed to examine the management of acute coronary syndromes (ACS) in Europe and the Mediterranean basin, and to compare adherence to guidelines with that reported in the first Euro Heart Survey on ACS (EHS-ACS-I), 4 years earlier ...
Takács, János, Boyko, Valentina, Mandelzweig, Lori, Werf, Frans, Van de, Kovács, Aranka, Danchin, Nicolas, Filippatos, Gerasimos, Bodonovits, István, Gitt, Anselm, Wallentin, Lars, Hasin, Yonathan, Hasdai, David, Behar, Shlomo, Kovács Szentes, Ferenc, Marrugat, Jaume, Csoti, Éva, Bueno, Hector, Préda, István, Battler, Alex   +18 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

A Feature Selection for Detection of Non ST Elevation Myocardial Infarction

2016 Computing in Cardiology Conference (CinC), 2016
A feature selection (FS) process of biomarkers for detecting Acute Myocardial Infarction (AMI) for Non ST Elevation patients (NSTEMI) is presented. FS has been applied by a retrospective analysis of biomarkers — high sensitivity cardiac troponin T (hs-cTnT), heart-type fatty acid-binding protein (H-FABP), creatine kinase-MB (CK-MB), myoglobin, GPBB ...
Cesar Oswaldo Navarro Paredes, Mary Jo Kurth, David J. McEneaney, James McLaughlin 0001   +3 more
openaire   +2 more sources

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes:the MRC-ILA Heart Study [PDF]

, 2014
AIMS: Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel-response to injury. ACS patients have raised serum markers of inflammation.
Greenwood, J.P., Hall, Alistair S., Rothman, A.M.K., Morton, Allison C., Foley, C., Chase, A., Greenwood, John P, Chase, Alex, Morton, Allison C, Wang, Duolao, Rothman, Alexander M K, Banya, Winston, Clarke, B., Gunn, J., Crossman, David C, Rothman, Alexander M. K., Crossman, David C., Flather, Marcus D, Rothman, Alexander M.K., Clarke, Bernard, Fox, Keith, Fox, K., Banya, W., Hall, Alistair S, Gunn, Julian, Flather, Marcus D., Greenwood, John P., Foley, Claire, Hall, A.S., Morton, A.C.   +29 more
core   +1 more source

Table_1_Prognosis Between ST-Elevation and Non-ST-elevation Myocardial Infarction in Older Adult Patients.DOCX

, 2022
Background: Whether there is a difference in prognosis between elderly patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) remains mysterious.Methods: We conducted a retrospective cohort study by ...
Shih-Sheng Chang (8543094), Hei-Tung Yip (6921803), Zhe-Wei Kuo (11893709), Chia-Hung Kao (173343), Shao-Hua Yu (11893712), Chiung-Ray Lu (11893706), Shih-Yi Lin (239494), Ke-Wei Chen (3905965), Hong-Mo Shi (11893715)   +8 more
core   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Long-term effects of autologous bone marrow stem cell treatment in acute myocardial infarction: factors that may influence outcomes [PDF]

, 2012
AIMS: To investigate whether there are important sources of heterogeneity between the findings of different clinical trials which administer autologous stem cell treatment for acute myocardial infarction (AMI) and to evaluate what factors may influence ...
Anthony Mathur, Fisher Sheila A., Doree Carolyn, Doree, C, Mike J Clarke, Carolyn Doree (162145), Enca Martin-Rendon, Mathur Anthony, Clarke, MJ, Martin-Rendon Enca, Susan J Brunskill, Brunskill, Susan J., Susan J. Brunskill (162133), Watt, SM, Sheila A. Fisher (162124), Clifford, DM, Mike J. Clarke (162164), Watt Suzanne M., Carolyn Doree, Clifford, David M., Fisher, Sheila A., Brunskill, SJ, Suzanne M Watt, David M. Clifford (162115), Martin-Rendon, E, David M Clifford, Watt, Suzanne M., Brunskill Susan J., Clifford David M., Enca Martin-Rendon (162178), Suzanne M. Watt (162171), Fisher, SA, Doree, Caroyln, Mathur, Anthony, Clarke Mike J., Clarke, Michael, Anthony Mathur (162155), Sheila A Fisher, Martin-Rendon, Enca, Mathur, A   +39 more
core   +2 more sources

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source