Results 131 to 140 of about 2,113,930 (331)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Tekutá teritorialita a hnutí al-Šabáb

Czech Journal of International Relations, 2020
The text presents a contribution to the study of territoriality of violent non-state actors in areas of limited internal state power projection. It presents the strategy of liquid territoriality as a survival strategy of the territorial violent non-state
Doboš, Bohumil
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Role of Non-State Actors in the Linguistic Policy in the Republic of Moldova

Международная аналитика
This article examines the evolving role of non-state actors in the politics of language, using the postSoviet Republic of Moldova as a case study. Over the past half-century, the increasing influence  of non-state actors in global political systems has ...
A. S. Tulum
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Connection men, pushers and migrant trajectories: examining the dynamics of the migration industry in Ghana and along routes into Europe and the Gulf States [PDF]

, 2019
This paper examines the inner workings and operational logic of the array of individuals, agencies, state and non-state actors, institutions and social networks that collectively make up the migration industry in Ghana.
Awumbila, Mariama, Deshingkar, Priya, Kandilige, Leander, Nikoi, Ebenezer, Teye, Joseph   +4 more
core  

Steganographer Identification

, 2019
Conventional steganalysis detects the presence of steganography within single objects. In the real-world, we may face a complex scenario that one or some of multiple users called actors are guilty of using steganography, which is typically defined as the
Breunig, Chen, Cortes, Erdogmus, Filler, Filler, Filler, Fridrich, Fridrich, Fridrich, Fridrich, Gretton, Guo, Hetzl, Holub, Holub, Holub, Holub, Ker, Ker, Ker, Ker, Ker, Ker, Ker, Ker, Kodovsky, Li, Li, Liu, Muandet, Pearson, Pevny, Pevný, Pevný, Pevný, Pevný, Rokach, Sahu, Sallee, Scholkopf, Shi, Song, Westfeld, Wu, Wu, Wu   +46 more
core   +1 more source

The Rise of Militant Non-State Actors in the Middle East: Consequences for the Statehood

Journal of Research in Social Sciences
In the great power rivalries, the state employs various tactics to enforce their agenda at the regional scale. It involves conducting the intelligence based operations, limited strikes or fostering partnerships with the non-state actors.
Dr. Syed Qandil Abbas, Syed Fraz Hussain Naqvi   +1 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source