Results 301 to 310 of about 225,445 (370)

Unsupervised Hierarchical Symbolic Regression for Interpretable Property Modeling in Complex Multi‐Variable Systems

Advanced Science, EarlyView.
UHSR translates complex chemical behavior into clear and explainable equations. Applied to thin‐layer chromatography, it automatically uncovers the mathematical rules linking a molecule's structure to its polarity. This approach matches the accuracy of advanced AI while providing interpretable results, earning greater trust from chemists. The method is
Siyu Lou, Chengchun Liu, Dongxiao Zhang, Yuntian Chen, Fanyang Mo   +4 more
wiley   +1 more source

Assessment of non-steroidal anti-inflammatory drugs use and its complications among pediatric patients at a private tertiary care hospital in Malaysia. [PDF]

BMC Pediatr
Low JYC, Sivanandy P, Ingle PV, Manirajan P.   +3 more
europepmc   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

Do Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Adversely Impact Fracture Healing? A Critical Review of the Literature. [PDF]

Curr Rev Musculoskelet Med
Stroud SG, Passfall L, Alam JS, Segreto FA, Baum R, Shah NV, Monsef JB, Paulino CB, Diebo BG.   +8 more
europepmc   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

Adrenergic blockers, statins, and non-steroidal anti-inflammatory drugs are associated with later age at onset in Parkinson's disease. [PDF]

J Neurol
Malatt C, Maghzi H, Hogg E, Tan E, Khatiwala I, Tagliati M.   +5 more
europepmc   +1 more source

CLINICAL OBSERVATIONS ON THE NEUROMUSCULAR BLOCKING ACTION OF ORG 9426, A NEW STEROIDAL NON-DEPOLARIZING AGENT

, 1990
J. Mark K. H. Wierda, A.P.M. DE WIT, Karel Kuizenga, S. Agoston   +3 more
openalex   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

From prescription patterns to drug safety: a closer look at non-steroidal anti-inflammatory drugs and analgesics in outpatient pharmacy. [PDF]

Front Pharmacol
Saeed ZM, Sridhar SB, Shareef J, Rashed Alsereidi AM.   +3 more
europepmc   +1 more source

The Effectiveness of Anti‐Adhesion Barriers on Prevention of Postoperative Adhesive Bowel Obstruction: Disease‐Free Survival Analysis

Annals of Gastroenterological Surgery, EarlyView.
We performed a survival analysis of abdominal gastroenterological cancer surgery cases with and without anti‐adhesive barriers, with the development of adhesive bowel obstruction as the outcome. The incidence of adhesive bowel obstruction was significantly lower in patients undergoing open or laparoscopic colorectal surgery in the anti‐adhesive ...
Shota Ebinuma, Susumu Kunisawa, Daisuke Takada, Kiyohide Fushimi, Akinobu Taketomi, Yuichi Imanaka   +5 more
wiley   +1 more source