Results 91 to 100 of about 13,491,336 (252)
Advanced Science, EarlyView.Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan +9 more
wiley +1 more source
The use of non-steroidal anti-inflammatory drugs in cerebrovascular diseases
, 2021 Cerebrovascular diseases (CVD) are a group of diseases resulting from ischemic or hemorrhagic conditions, causing neurological deficits. In developed countries, CVD are the third leading cause of death and the leading cause of disability. In ischemic and
Demir, Caner Feyzi, Tasci, Irem
core +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
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Management of patients with chronic nonspecific lumbar pain
Медицинский совет, 2019 Chronic lumbar pain (CLP) is one of the most common causes of temporary disability. Both the elimination of specific causes of pain and the assessment of social and psychological factors of pain management are of great importance in the examination of ...
V. A. Parfenov
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita +4 more
wiley +1 more source
Electro‐Organic Synthesis at a Stable Oil/Water/Solid Three‐Phase Interface Reactor
Angewandte Chemie, EarlyView.A porous membrane electrode (PME) reactor is developed to promote oil/water/solid three‐phase interfacial contact for electro‐organic synthesis. By promoting the formation of an oil/water interfacial region within or near an amphiphilic catalytic layer, the reactor enables efficient conversion of water‐insoluble organic reactants in aqueous ...
Deyin Chen +7 more
wiley +2 more sources
Journal of Inflammation, 2010 The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and identification of immune selective anti-inflammatory agents of salivary origin.
Befus A Dean +3 more
doaj +1 more source
Autonomous AI‐Driven Design for Skin Product Formulations
Advanced Intelligent Discovery, EarlyView.This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy +5 more
wiley +2 more sources
MoleculesNitric esters are among the compounds that can liberate nitrogen monoxide (NO) in the organism. Due to the vasodilatation caused by nitrogen monoxide, NO-donors have been shown to protect endothelial function, acting as vasodilators, promoting efficient ...
Paraskevi Tziona +4 more
doaj +1 more source