Results 111 to 120 of about 13,032,507 (249)

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong   +7 more
wiley   +1 more source

Peripheral nerve system development, diclofenac sodium toxicity, and melatonin protection

open access: yes, 2021
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently employed for the treatment of pain, fever, and inflammation. Diclofenac sodium (DS) exhibits potent anti-inflammatory, analgesic, and antipyretic effects.
Kaplan,S.   +3 more
core  

Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu   +5 more
wiley   +1 more source

Biomimetic Nanofiber Scaffold Coated With Acellular Matrices for Uterine Myometrial Tissue Engineering

open access: yesAdvanced NanoBiomed Research, EarlyView.
Schematic representation of acellular matrix generation from human uterine fibroblast cells, coating on polycaprolactone electrospun nanofibers, and subsequent in vitro and in vivo characterization. A tissue‐engineered scaffold tailored for uterine myometrium‐specific regeneration is designed. The electrospinning technique was used to fabricate aligned
Srividya Hanuman   +3 more
wiley   +1 more source

EFFICACY OF IITRAVENOUS KETOROLAC IN POST ELETRRO-CONVULSIVE THERAPY (ECT) HEADACHE

open access: yesPakistan Armed Forces Medical Journal, 2020
Objectives: To compare the mean headache score after single dose Intra-venous (I/V) ketorolac administered as part of General Anaesthesia (GA) following Electro-convulsive Therapy (ECT) versus placebo.
Muhammad Umer   +2 more
doaj  

Atividade anti-inflamatória do ácido arjunóli-co extraído de Combretum leprosum Mart. & Eicher (Combretaceae) em camundongos [PDF]

open access: yes, 2011
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.Combretum leprosum (mofumbo ou cipoaba) é um arbusto nativo do Brasil utilizado na medicina popular para o tratamento de hemorragias, como sedativo ...
Cabrera, Celeste Heisecke
core  

Sorption and Desorption Dynamics of Selected Non-steroidal Anti-inflammatory Drugs Agricultural Systems

open access: yes, 2016
This study shows that the sorption coefficients of four individual NSAIDs and their mixture to the soil and soil-biosolid matrix follow the order: DCF > NPX > KTF > IBF.
Zhang, Yu
core  

Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
This study include design and synthesis of 2 derivatives of compounds consisting of mefenamic acid, glycine and organic nitrates (2-nitrooxy ethanol or 1,3-dinitrooxy-2-propanol).
Ahmed A. Sadon, Ahlam J. Qasir
doaj  

Influence of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection in patients with early gastric cancer

open access: yesDEN Open
Objectives The causes of drug‐induced gastroduodenal injuries primarily include antithrombotic drugs, including low‐dose aspirin, non‐steroidal anti‐inflammatory drugs, and corticosteroids.
Kazuto Takahashi   +10 more
doaj   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

open access: yesAngewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon   +9 more
wiley   +1 more source

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