Results 81 to 90 of about 169,582 (297)

Antipyretic activity of azima tetracantha in experimental animals [PDF]

, 2011
In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for antipyretic activity in rats using Brewer’s yeast induced Pyrexia. The leaves of A.
Tajuddin Nargis Begum, Mohamed Hussain Muhammad Ilyas, Arumugam Vijaya Anand , Int J Cur Biomed Phar Res.
core  

Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions [PDF]

, 2017
BACKGROUND: Traumatic corneal abrasions are relatively common and there is a lack of consensus about analgesia in their management. It is therefore important to document the clinical efficacy and safety profile of topical ophthalmic non-steroidal anti ...
Alberti, Brahma, Calder, Calder, Chiapella, Donnenfeld, Edwards, Egger, Fenton, Glanville, Goyal, Guidera, Higgins, Jayamanne, Kaiser, Lau, Lee, Lim CHL Turner, Lin, McCabe, Patrone, Pharmakakis, Sabri, Shields, Solomon, Szucs, Thyagarajan, Watson, Weaver, Wilson, Yagci, Younger   +31 more
core   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Risk of myocardial infarction with use of selected nonsteroidal anti-inflammatory drugs in spondyloarthritis patients [PDF]

, 2017
BACKGROUND: Spondyloarthritis (SpA) is associated with increased risk of myocardial infarction (MI); the risk may be due to the underlying inflammatory disease, or also due to medications that increase MI risk, such as certain non-steroidal anti ...
Dubreuil, Maureen
core   +1 more source

Developing a complex intervention to improve prescribing safety in primary care:mixed methods feasibility and optimisation pilot study [PDF]

, 2014
Objectives (A) To measure the extent to which different candidate outcome measures identified high-risk prescribing that is potentially changeable by the data-driven quality improvement in primary care (DQIP) intervention.(B) To explore the value of ...
Dreischulte, Tobias, Grant, Aileen M., Guthrie, Bruce   +2 more
core   +7 more sources

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Non-steroidal Anti-inflammatory Drug Prescriptions in Living Kidney Donors: A Retrospective Cohort Study

Canadian Journal of Kidney Health and Disease
Background: Current guidelines recommend that living kidney donors should avoid non-steroidal anti-inflammatory drugs due to their potential nephrotoxic effects. It is unclear if physicians are adhering to this recommendation.
Mikayla I. Laube, Robert R. Quinn, Pietro Ravani, Krista L. Lentine, Alix Clarke, Rachel Jeong, Jason Bau, Ngan N. Lam   +7 more
doaj   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

ANTI-INFLAMMATORY THERAPY BY FENSPIRIDE IN PATIENTS WITH PATHOLOGY OF UPPER AND LOWER RESPIRATORY TRACTS

Медицинский совет, 2016
In the treatment of patients with diseases of the upper and lower respiratory tract it is necessary to conduct anti-inflammatory therapy. Up to the present time two groups of anti-inflammatory drugs were used: corticosteroids (CSs) and non-steroidal ...
O. A. TSVETKOVA
doaj   +1 more source

Experimental Study of Antimicrobial Properties and Acute Toxicity of the Peo-based Combined Suppositories [PDF]

, 2019
Aim. The research of antimicrobial and toxicological parameters of a promising pharmaceutical composition with indole-3-carbinol and meloxicam in the form of rectal suppositories.Materials and methods.
Ravshanov, T. (Tymur), Ruban, O. (Olena), Zaychenko, G. (Ganna), Zaychenko, V. (Volodymyr), Zhemerova, K. (Kateryna)   +4 more
core   +3 more sources