Results 101 to 110 of about 1,449,640 (302)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

40 Years of Surgical Education in Kenya; What Does the Future Hold?

open access: yesThe Annals of African Surgery, 2016
Surgical education structure and systems worldwide have changed gradually to incorporate not only the traditional competencies of medical knowledge, patient care and technical skills but other non-technical skills of communication, systems based practice
Ojuka KD
doaj  

Video analysis of real‐life shoulder dystocia to assess technical and non‐technical performance

open access: yesActa Obstetricia et Gynecologica Scandinavica
Introduction Managing obstetric shoulder dystocia requires swift action using correct maneuvers. However, knowledge of obstetric teams' performance during management of real‐life shoulder dystocia is limited, and the impact of non‐technical skills has ...
Kristiane Roed Hjorth‐Hansen   +6 more
doaj   +1 more source

A systematic literature review of simulation models for non-technical skill training in healthcare logistics

open access: yesAdvances in Simulation, 2018
Background Resource allocation in patient care relies heavily on individual judgements of healthcare professionals. Such professionals perform coordinating functions by managing the timing and execution of a multitude of care processes for multiple ...
Chen Zhang   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Encourage. Empowering People. Annual Report 2012 [PDF]

open access: yes, 2013
Peter Löscher, President of the Siemens Stiftung Board of Trustees, on behalf of the Board: Siemens Stiftung aims to contribute to positive changes in society with technical solutions, concrete concepts, and platforms for knowledge transfer.

core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Oral presentation preparation of engineering students of Pakistan for world of work: are they really prepared? [PDF]

open access: yes, 2012
Oral presentations have acquired significant position in the world of work. Industry demands engineering graduates equipped with technical and non technical skills to uplift business of organizations at international level.
Habil, Hadina   +3 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

An Interaction Centred Approach to the teaching of Non-technical Skills in a Virtual Environment

open access: yes, 2016
In most domains involving expert knowledge, there is a number of cognitive and social factors influencing how efficient one human being is at correctly assessing and responding to certain situations.
Bourrier, Yannick   +3 more
core   +1 more source

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