Results 191 to 200 of about 478,729 (278)

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

High-Efficiency Analytical Protein A Columns for High Sensitivity Monoclonal Antibody Titer Analysis. [PDF]

Anal Chem
Muriithi B, Gritti F, Gilar M, Sarisozen Y, Lauber M, Wyndham K.   +5 more
europepmc   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

The "Radicular Tank": A Novel Concept in Endodontics Achieved with the MEA Inverse Taper^® Technique. [PDF]

Dent J (Basel)
Messina G, Bonandi G, Marchica M, Longo M, d'Alcontres LS, Distefano L, Cacioppo A, Maltagliati PE, Bugea C, Pedullà E, Bardellini E.   +10 more
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Approximate quantum circuit compilation for proton-transfer kinetics on quantum processors.

Phys Chem Chem Phys
Kovyrshin A, Manawadu D, Altamura E, Pennington G, Jaderberg B, Brandhofer S, Nykänen A, Miller A, Talarico W, Knecht S, Pavošević F, Baiardi A, Tacchino F, Tavernelli I, Mensa S, Crain J, Tornberg L, Broo A.   +17 more
europepmc   +1 more source

Koina: Democratizing machine learning for proteomics research. [PDF]

Nat Commun
Lautenbacher L, Yang KL, Kockmann T, Panse C, Gabriel W, Bold D, Kahl E, Chambers M, MacLean BX, Li K, Yu F, Searle BC, Wilburn DB, Shahneh MRZ, Hong Y, Tang H, Wang M, Gabriels R, Bouwmeester R, Devreese R, Angelis J, Sabidó E, Schmidt TK, Nesvizhskii AI, Wilhelm M.   +24 more
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Two-factor authentication for intellectual property transactions based on improved zero-knowledge proof. [PDF]

Sci Rep
Mo S, Feng W, Huang M, Feng S, Wang Z, Li Y.   +5 more
europepmc   +1 more source

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source