Results 51 to 60 of about 1,150,684 (289)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The First-Order Theory of Ground Tree Rewrite Graphs [PDF]
Logical Methods in Computer Science, 2014 We prove that the complexity of the uniform first-order theory of ground tree rewrite graphs is in ATIME(2^{2^{poly(n)}},O(n)). Providing a matching lower bound, we show that there is some fixed ground tree rewrite graph whose first-order theory is hard ...
Stefan Göller, Markus Lohrey
doaj +1 more source
Analytical Solution for Bichromatic Waves on Linearly Varying Currents
Mathematics, 2022 It is well-known that the bound long waves play an important role on beach morphology. The existence of the current will modify the intensity of the waves.
Mu-Jung Lee, Shih-Chun Hsiao
doaj +1 more source
New non-uniform lower bounds for uniform classes
, 2016 We strengthen the nondeterministic hierarchy theorem for non-deterministic polynomial time to show that the lower bound holds against sub-linear advice. More formally, we show that for any constants d and d' such that 1 <= d < d', and for any time-constructible bound t=o(n^d), there is a language in NTIME(n^d) which is not in NTIME(t)/n^{1/d ...
Fortnow, Lance, Santhanam, Rahul
openaire +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Open Engineering, 2016 Paper deals with the non-uniform covering method that is aimed at deterministic global optimization. This method finds a feasible solution to the optimization problem numerically and proves that the obtained solution differs from the optimal by no more ...
Evtushenko Yury, Posypkin Mikhail
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Corrosion models of a mounded horizontal pressure vessel in a probabilistic approach [PDF]
Archives of Civil EngineeringThe computations of fuel tanks are bound to cover uncertainties related to geometric and material imperfections, post-welding stresses, non-uniform settlement, and shell degradation due to corrosion.
Mateusz Sondej +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source