Results 61 to 70 of about 11,363,734 (290)

Bounded cohomology and non-uniform perfection of mapping class groups [PDF]

Inventiones mathematicae, 2001
Using the existence of certain symplectic submanifolds in symplectic 4-manifolds, we prove an estimate from above for the number of singular fibers with separating vanishing cycles in minimal Lefschetz fibrations over surfaces of positive genus. This estimate is then used to deduce that mapping class groups are not uniformly perfect, and that the map ...
Hisaaki Endo, Dieter Kotschick
openaire   +3 more sources

On wind turbine loading induced by non-uniform approaching flow at high Reynolds numbers [PDF]

, 2022
Influences of non-uniform incoming flow on the wind turbines blades forces and root bending moments (RBMs) are not fully understood. To advance our current understanding, numerical studies of a three-bladed horizontal axis wind turbine with cylinders ...
Z. Yang, Yang, Z., Ahmadi, M., M. H. B. Ahmadi   +3 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Fast Parameter Estimation Algorithm for Near-field Non-circular Signals

Leida xuebao, 2020
In this paper, a fast parameter estimation algorithm for near-field non-circular signals is proposed, which is based on symmetric, uniform, and linear array, that decouple the near-field steering vector via non-circularity and symmetry.
Jiaqi SONG, Haihong TAO
doaj   +1 more source

Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands. [PDF]

PLoS ONE, 2015
Rho GTPases play important roles in many aspects of cell migration, including polarity establishment and organizing actin cytoskeleton. In particular, the Rho GTPase Rac1 has been associated with the generation of protrusions at leading edge of migrating
Vinal V Lakhani, Elizabeth Hinde, Enrico Gratton, Timothy C Elston   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Bound states around vacuum in scalar ModMax model

Physics Letters B
In this work, we consider a two-dimensional scalar field model inspired by the dimensional reduction of a four-dimensional ModMax theory. Upon projecting out the 4D theory down to a 2D theory we obtain a theory which presents a constant electric field ...
F.A. Brito, M.A. Marques, R. Menezes, E. Passos   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source