Results 51 to 60 of about 10,757,449 (291)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Sharp lower bounds on the extractable randomness from non-uniform sources

open access: yesInformation and Computation, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Boris Skoric   +3 more
openaire   +6 more sources

Non Uniform Selection of Solutions for Upper Bounding the 3-SAT Threshold [PDF]

open access: yes, 2010
28 pages; presentation ...
Thomas Hugel, Yacine Boufkhad
openaire   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Uniform hypergraphs containing no grids [PDF]

open access: yes, 2013
A hypergraph is called an r×r grid if it is isomorphic to a pattern of r horizontal and r vertical lines, i.e.,a family of sets {A1, ..., Ar, B1, ..., Br} such that Ai∩Aj=Bi∩Bj=φ for 1 ...
Füredi, Zoltán, Ruszinkó, Miklós
core   +1 more source

A numerical comparative study for the singularly perturbed nonlinear Volterra-Fredholm integro-differential equations on layer-adapted meshes

open access: yesMiskolc Mathematical Notes
This article deals with the singularly perturbed nonlinear Volterra-Fredholm integro-differential equations. Firstly, some priori bounds are presented.
Baransel Gunes, Musa Cakir
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Monochromatic loose paths in multicolored $k$-uniform cliques [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2019
For integers $k\ge 2$ and $\ell\ge 0$, a $k$-uniform hypergraph is called a loose path of length $\ell$, and denoted by $P_\ell^{(k)}$, if it consists of $\ell $ edges $e_1,\dots,e_\ell$ such that $|e_i\cap e_j|=1$ if $|i-j|=1$ and $e_i\cap e_j=\emptyset$
Andrzej Dudek, Andrzej Ruciński
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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