Results 61 to 70 of about 431,042 (280)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A numerical comparative study for the singularly perturbed nonlinear Volterra-Fredholm integro-differential equations on layer-adapted meshes

Miskolc Mathematical Notes
This article deals with the singularly perturbed nonlinear Volterra-Fredholm integro-differential equations. Firstly, some priori bounds are presented.
Baransel Gunes, Musa Cakir
doaj   +1 more source

Growth of maps, distortion in groups and symplectic geometry

, 2000
In the present paper we study two sequences of real numbers associated to a symplectic diffeomorphism: the uniform norm of the differential of its n-th iteration and the word length of its n-th iteration.
Polterovich, Leonid
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

3-D Beamforming Training Using Mutually Unbiased Bases for Cell Discovery in mm-Wave Systems

IEEE Access, 2023
Beamforming training or cell discovery (CD) is a fundamental procedure in millimeter wave communication systems in which the user detects the presence of a base station, acquires the identity of that base station, and finds suitable beamforming ...
P. Rashmi, A. Manoj, Arun Pachai Kannu
doaj   +1 more source

New Phase Diagram for Black Holes and Strings on Cylinders

, 2003
We introduce a novel type of phase diagram for black holes and black strings on cylinders. The phase diagram involves a new asymptotic quantity called the relative binding energy.
Choptuik M W, De Smet P-J, Emparan R Myers R C, Gibbons G W, Gregory R, Gubser S S, Harmark T, Harmark T Obers N A, Harmark T Obers N A, Horowitz G T, Kol B, Kol B, Kol B, Niels A Obers, Shiromizu T Ida D Tomizawa S, Sorkin E Piran T, Townsend P K, Townsend P K, Traschen J, Traschen J Fox D, Troels Harmark, Wiseman T, Wiseman T, Witten E   +23 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Visibility maps of realistic terrains have linear smoothed complexity

Journal of Computational Geometry, 2010
We study the complexity of the visibility map of terrains whose triangles are fat, not too steep and have roughly the same size. It is known that the complexity of the visibility map of such a terrain with n triangles is Θ(n2) in the worst case. We prove
Mark de Berg, Herman Haverkort, Constantinos P. Tsirogiannis   +2 more
doaj   +1 more source

Convergence of densities of some functionals of Gaussian processes [PDF]

, 2013
The aim of this paper is to establish the uniform convergence of the densities of a sequence of random variables, which are functionals of an underlying Gaussian process, to a normal density.
Hu, Yaozhong, Lu, Fei, Nualart, David
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source