Results 61 to 70 of about 22,626 (299)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Transceiver Optimization for mmWave Line-of-Sight MIMO Systems Using Hybrid Arrays

Micromachines, 2023
The performance of millimeter wave (mmWave) line-of-sight multiple input multiple output (LOS MIMO) systems using hybrid arrays of planar subarrays was studied.
Junwen Deng, Hang Li, Jian Andrew Zhang, Xiaojing Huang, Zhiqun Cheng   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Using necessary optimality conditions for acceleration of the nonuniform covering optimization method

Open Engineering, 2016
Paper deals with the non-uniform covering method that is aimed at deterministic global optimization. This method finds a feasible solution to the optimization problem numerically and proves that the obtained solution differs from the optimal by no more ...
Evtushenko Yury, Posypkin Mikhail
doaj   +1 more source

Non-uniform stability for bounded semi-groups on Banach spaces

Journal of Evolution Equations, 2008
Let S(t) be a bounded strongly continuous semi-group on a Banach space B and – A be its generator. We say that S(t) is semi-uniformly stable when S(t)(A + 1)−1 tends to 0 in operator norm. This notion of asymptotic stability is stronger than pointwise stability, but strictly weaker than uniform stability, and generalizes the known logarithmic ...
Batty, C, Duyckaerts, T
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Bayesian Model Updating of Structural Parameters Using Temperature Variation Data: Simulation

Machines
Finite element (FE) models are widely used in structural health monitoring to represent real structures and assess their condition, but discrepancies often arise between numerical and actual structural behavior due to simplifying assumptions, uncertain ...
Ujjwal Adhikari, Young Hoon Kim
doaj   +1 more source

The non-relativistic limit of the Vlasov–Maxwell system with uniform macroscopic bounds [PDF]

, 2022
Nicolas Brigouleix, Daniel Han-Kwan
openalex   +1 more source