Results 91 to 100 of about 23,393,866 (298)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Pour une éducation non-violente : enjeux pédagogiques et sociaux /
, 1994 Plusieurs textes dont le thème est lié à la violence, la non-violence et les enfants, les droits des enfants, les pédagogies nouvelles, les conflits et les éléments de résolution.Bibliogr. p.
Bayada, Bernadette,
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Lien Social et PolitiquesLa communauté de La Borie Noble semble avoir aujourd’hui renoncé à l’utopie ascétique de l’Ordre Laborieux de l’Arche fondé par Lanza del Vasto en 1948, dont elle fut autrefois la Terre Capitale.
Aurélien Remy
doaj +1 more source
Specialist family violence services: the heart of an effective family violence system
, 2015 The Victorian Royal Commission into Family Violence is an extraordinary opportunity to interrogate and strengthen the family system in this state. Unprecedented increase in family violence incidents has placed demands on the system - the specialist ...
Domestic Violence Victoria
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Subhas Chandra Bose: l’altra anima dell’India
Diacronie. Studi di Storia Contemporanea, 2019 In the years in which the nationalist indipendence movement develops in India and non violent politics of Gandhi “the Mahatma” made a large part of population that followed the controversial of Subhas Chandra Bose with enthusiasm and confidence.
Claudio Usai
doaj
Thoreau’s civil disobedience from Concord, Massachusetts: global impact
Frontiers in Political ScienceMajor wars or battles, political revolutions, scientific breakthroughs, or profound social changes often constitute substantial historical turning points.
Saahith Reddy
doaj +1 more source
Organized violence 1989–2023, and the prevalence of organized crime groups
Journal of Peace ResearchThis article examines trends in organized violence based on new data from the Uppsala Conflict Data Program (UCDP). In 2023, fatalities from organized violence decreased for the first time since the rapid increase observed in 2020, dropping from 310,000 ...
Shawn Davies +3 more
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source