Results 121 to 130 of about 23,393,866 (298)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
, 2012 This Issues Paper reviews some of the available sources of data on family violence, assesses strengths and limitations of these data sources for measuring trends in family violence, and seeks to assist the reader to develop an understanding of the issues
Gulliver, P, Fanslow, JL
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Freedom from Violence: Tools for Working with Trauma, Mental Health and Substance Use: Resource Tool Kit [PDF]
, 2007 First paragraph: The aim of this tool kit is to actively engage readers in applying a feminist analysis to women's experiences of mental health, substance use and past and current experiences of violence.
Ziegler, Maggie +10 more
core
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Other title: Comprehensive plan to prevent sexual and domestic violence in Kansas
, 2012 "The Kansas Coalition Against Sexual and Domestic Violence (KCSDV), the Kansas Department of Health and Environment (KDHE), and the Kansas Sexual and Domestic Violence Primary Prevention Planning Committee are pleased to present Reweaving the Social ...
Kansas Sexual and Domestic Violence Primary Prevention Planning Committee.
core +1 more source
Extent, nature, and consequences of intimate partner violence [PDF]
This report presents findings from the National Violence Against Women Survey on the extent, nature, and consequences of intimate partner violence in the United States.The survey, which was conducted from November 1995 to May 1996, consisted of telephone
core