Results 131 to 140 of about 23,393,866 (298)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
, 2011 HV6626.22.C665a; Family violence -- Connecticut; Intimate partner violence -- Connecticut; Victims of family violence -- Services for ...
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Pitie et Non-violence dans 1S 24-26 : Cas de David Versus Saül et Nabal
Old Testament Essays, 2019 This article takes root in the reading of the narrative sequence which we find 1S 24-26 where three narratives follow one after another: at first to David who leads Saul to Engaddi, then to Abigail who diverts David from his plan to avenge Nabal, and ...
Augustin L. Kagunge
doaj +1 more source
Facts everyone should know about intimate partner violence, sexual violence & stalking : by understanding these types of violence, we can take action to stop them before they start in our communities [PDF]
The infographic highlights key findings from the National Intimate Partner and Sexual Violence Survey NISVS) and presents facts everyone should know about intimate partner violence, sexual violence, and stalking ...
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
L’art et la guérison—Des impératifs éthiques dans Jardin secret de Julien Kilanga Musinde
Tydskrif vir Letterkunde, 2017 This article sets out to analyse a trend in literary (re)positioning in the context of socio-political confrontation. In keeping with the literary approach adopted by Julien Kilanga Musinde in the novel Jardin secret (2010), the article will focus on ...
Patrick Kabeya Mwepu
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