Results 151 to 160 of about 187,835 (306)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Multilevel correlates of childhood violence in refugee settings: findings from the Ethiopia humanitarian violence against children and youth survey. [PDF]

Glob Health Action
Dessie Y, Wandera B, Odwe G, Obare F, Habteyesus D, Muthuri S, Seruwagi G, Namarra U, Nur A, Kisaakye P, Kabiru CW, Undie CC, Wado YD.   +12 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Childhood exposure to interpersonal and animal-directed violence: adversity profiles and adult suicidality. [PDF]

Front Psychiatry
McDonald SE, Tomlinson C, Freedenthal S, Bright CL, Malone A, Nicotera N, Kogan L, Van Buiten H, Ford J.   +8 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Determinants of domestic violence against women in Cambodia: How digital access, media exposure, motorcycle ownership, and partners' alcohol use matter. [PDF]

PLoS One
Um S, Suong S, Sieng C, Heng S, Marie Ku G, Heng S.   +5 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The experiences of midwives with violence from patients, their relatives and friends: A study in perinatal center in Lithuania. [PDF]

Eur J Midwifery
Mikėnaitė M, Barakat M, Petrošienė B, Kliučinskas M, Bartusevičius A, Liepinaitienė A, Bartusevičienė E.   +6 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Male Victims of Domestic Violence: Clinical and Behavioral Insights from an Italian Hospital-Based Study. [PDF]

Behav Sci (Basel)
Focardi M, D'Onofrio P, Cestaro M, Guerini M, Ermini FR, Carnevali M, Grifoni R, Gualco B, Bianchi I, Pinchi V, Defraia B.   +10 more
europepmc   +1 more source