Results 151 to 160 of about 11,612,374 (304)

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

First whole-genome detection of dengue virus in urban Aedes aegypti from Southern Brazil.

PLoS Neglected Tropical Diseases
Dengue virus (DENV) is a major global health threat whose expansion into temperate regions has been facilitated by climate change and vector adaptation.
Amanda Cupertino de Freitas, Sara Cândida Ferreira Dos Santos, Luiz Marcelo R Tomé, Vagner Fonseca, Talita Émile Ribeiro Adelino, Natália R Guimarães, Felipe C M Iani, Keldenn Moreno, Bruna Regina Diniz Souza, Victor Augusto Isidoro Maia, Getúlio Dornelles Souza, Ellen Caroline Nobre Santos, Lívia Victória Rodrigues Baldon, Rafaela Luiza Moreira, Maria Eduarda Calazans Rodrigues, Isaque João da Silva de Faria, João Paulo Pereira de Almeida, Luiz Carlos Junior Alcantara, Marta Giovanetti, Álvaro Gil Araujo Ferreira   +19 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Application of Liposomes in Non-Viral Vectors

Highlights in Science, Engineering and Technology
With the development of pathology, the traditional way of drug delivery is gradually unable to meet the needs of increasingly complex cancers, genetic diseases, and other drug delivery needs, so gene delivery was born. Precise, efficient delivery reduces damage to normal cells, improves treatment effect, and reduces the amount of drug used, hence the ...
openaire   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Editorial: Vector-based gene delivery in cancer immunotherapy

Frontiers in Immunology
Ning Cheng, Xiaoyue Yang, Dan Chen, Chun Xu, Chun Xu   +4 more
doaj   +1 more source

Non-viral vector based gene transfection with human induced pluripotent stem cells derived cardiomyocytes. [PDF]

Sci Rep, 2019
Tan S, Tao Z, Loo S, Su L, Chen X, Ye L.
europepmc   +1 more source

Viral vectors : gene therapy and neuroscience applications /

, 1995
Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into ...
Loewy, Arthur D., Kaplitt, Michael G.
core  

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source