Results 101 to 110 of about 943,588 (293)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

"Stop the World I want to Get Off" Flyer

open access: yes, 1970
A flyer for the Western Massachusetts Chapter of ANTA production of "Stop the World I Want to Get Off" a musical comedy by Leslie Bricusse and Anthony Newley. The play was performed in February 1970 in Moses Hall of the Beveridge Center on the campus of
ANTA (Organization) -- Western Massachusetts Chapter;
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Graduate recital, band conducting. Beauregard, P., 1999

open access: yes, 2016
Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, April 16, 1999, 11:00 a.m., the 489th concert of the School of Music's 1998-1999 season.Western Michigan University Symphonic Band ...
Beauregard, Patrick
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

The economic development of the Western Balkans: The importance of non-EU actors

open access: yes, 2019
This chapter seeks to evaluate the role and the relative importance of non-EU countries for the Western Balkan economies and their future economic development,including China, Russia, Turkey and the USA. The role of non-EU countries in the Western Balkan
Uvalic, Milica, Bonomi, Matteo
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Toward a Non-Hegemonic World Sociology

open access: yes, 2017
This blog presents the on going process of a discussion taking place between sociologists from all over the world who seek to define a non-hegemonic world sociology.
Éric Macé
core  

Lao PDR - Investment Climate Assessment : Policies to Promote Growth in the Non-Resource Sectors

open access: yes, 2011
The second Lao PDR investment climate assessment identifies the key constraints of the country's non-resource sector firms. This Assessment summarizes the results of a national survey conducted in late ...
World Bank
core   +1 more source

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