Results 61 to 70 of about 943,588 (293)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Revised framework to address TB-HIV co-infection in the Western Pacific Region [PDF]
1. Introduction. -- 2. Background . -- 3. Conceptual framework -- 4. TB-HIV surveillance -- 5. HIV testing in TB patient care settings -- 6. Intensified TB case-finding in HIV care settings. -- 7. Treatment for people with both TB and HIV -- 8.
World Health Organization Regional Office for the Western Pacific.
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Migration, translation, and transformation of western urban planning models
City, Territory and Architecture, 2020 People, ideas, lifestyles, cultures, architecture and urban planning models have invariably traversed the world as a consequence of military compulsions, political goals, commercial motivations, or aspirational values.
Pilar Maria Guerrieri
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2016 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, October 11, 1998, 3:00 p.m., the 53rd concert of the School of Music's 1998-1999 season.University Symphony Orchestra, Bruce J. Uchimura, conductor.
Western Michigan University Symphony Orchestra
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Science and Technology in Non‐Western Cultures
Zygon, 1999 Seline's edited volume relevates non‐Western interaction between religious and scientific domains of human intellectual history. Middle Eastern, South Asian, and Chinese thinkers have played central roles in pursuing intellectual inquiry into topics of ...
doaj +2 more sources