Results 81 to 90 of about 943,588 (293)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
University Symphony Orchestra, October 25, 1985
, 2014 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, October 25, 1985, 8:00 p.m., the 50th concert of the School of Music's 1985-1986 season.University Symphony Orchestra ; Anthony Elliott, conductor ...
Western Michigan University. Symphony Orchestra +1 more
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
University Symphonic Band, October 27, 1996
, 2016 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, October 27, 1996, 3:00 p.m., the 90th concert of the School of Music's 1996-1997 season.University Symphonic Band, Robert L. Spradling, conductor ;
Western Michigan University. Symphonic Band
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Sisterhood and "Doing Good": Asymmetries of Western Feminist Location, Access and Orbits of Concern
Feminist Philosophy Quarterly, 2019 There are a variety of discourses and practices that position Western feminists (and Western political subjects more generally) as people who have a moral and political obligation to concern themselves with the welfare, suffering, or empowerment of non ...
Uma Narayan
doaj +1 more source
University Concert Band, April 2, 2000
, 2016 Recorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, April 2, 2000, 3:00 p.m., the 457th concert of the School of Music's 1999-2000 season.University Concert Band, John Lychner, conductor ; Douglas L.
Western Michigan University. Concert Band
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Western Balkans Urban Mobility Initiative - Summary Report
The six Western Balkans (WeBa) countries, composed of Albania, Bosnia and Herzegovina, Kosovo, North Macedonia, Montenegro, and Serbia, have undergone major economic transformations over the past 15 years ...
World Bank
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source