Results 61 to 70 of about 21,988,579 (298)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Non-parametric fitting of nonlinear equations to experi- mental data without use of initial guessing: a basic computer program

open access: yesBrazilian Archives of Biology and Technology, 2000
In this work, we present a non-parametric method, and the appropriate computer program, for fitting nonlinear multiparametric equations to experimental data. Our method is followed by computation of confidence limits of the parameter estimates.
Emmanuel M. Papamichael   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Estimating Position of Mobile Terminals with Survey Data

open access: yesEURASIP Journal on Advances in Signal Processing, 2002
Estimating the position of mobile terminals is an important problem for cellular networks. This paper describes low cost methods of locating mobile terminals in urban environments.
McGuire Michael   +2 more
doaj   +1 more source

Necessary auxiliary background for efficient use of an existing computer program of non-parametric fitting of nonlinear equations

open access: yesBrazilian Archives of Biology and Technology, 2009
This work constituted a significant contribution for more efficient use of a valuable computer program of non-parametric fitting of nonlinear multiparametric equations to experimental data.
Emmanuel M. Papamichael   +1 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

ESTIMATING NON-PARAMETRIC AND PARAMETRIC TRANSFORMATION FUNCTIONS FROM SURVEY DATA: AN APPLICATION OF MINIMUM CROSS-ENTROPY [PDF]

open access: yes
A model of a (convex) technology of representative and non-representative firms in a heterogeneous sector is presented in non-parametric and parametric versions. The heterogeneity is specified with error terms.
Hoveid, Oyvind
core  

Non-linearities in electricity demand and temperature: Parametric versus non-parametric methods

open access: yes, 1997
This paper investigates the relationship between outside air temperature and the residential demand for space heating energy. These non-linearities are investigated empirically using high frequency panel data for a sample of UK households, and both ...
Henley, Andrew, Peirson, John D.
core   +1 more source

Non-parametric policy search with limited information loss

open access: yes, 2017
Learning complex control policies from non-linear and redundant sensory input is an important challenge for reinforcement learning algorithms. Non-parametric methods that approximate values functions or transition models can address this problem, by ...
Gerhard Neumann (17164168)   +2 more
core   +3 more sources

Parametric vs. non-parametric methods for estimating option implied risk-neutral densities: the case of the exchange rate Mexican peso – US dollar

open access: yesEnsayos Revista de Economía, 2008
This research paper presents statistical comparisons between two methods that are commonly used to estimate option implied Risk-Neutral Densities (RND). These are: 1) mixture of lognormals (MXL); and, 2) volatility function technique (VFT). The former is
Guillermo Benavides Perales   +1 more
doaj  

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