Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Parametric vs. non-parametric methods for estimating option implied risk-neutral densities: the case of the exchange rate Mexican peso – US dollar. [PDF]
This research paper presents statistical comparisons between two methods that are commonly used to estimate option implied Risk-Neutral Densities (RND). These are: 1) mixture of lognormals (MXL); and, 2) volatility function technique (VFT). The former is
Israel Felipe Mora Cuevas +1 more
core
Non-parametric contextual stochastic search
, 2016 Stochastic search algorithms are black-box optimizer of an objective function. They have recently gained a lot of attention in operations research, machine learning and policy search of robot motor skills due to their ease of use and their generality ...
Gerhard Neumann (17164168) +3 more
core +2 more sources
علوم آب و خاک, 2019 The effects of climate change can be released from the surface to the soil depth, thereby affecting soil thermal regime. Thermal energy in the soil plays a very important role in causing climate changes. In this study, for the assessment and detection of
S. Shiukhy Soqanloo +2 more
doaj
Trend Analysis and Change Points in Time Series of Water Level of Shallow and Deep Wells in Gorganrood Watershed [PDF]
علوم آب و خاک, 2023 A quantitative study of groundwater resources and accurate monitoring of changes over time, especially in areas facing limited water resources, is considered essential for proper management and sustainable exploitation of these resources.
T. Mohammadi +3 more
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Comparing non-parametric ensemble methods for document clustering [PDF]
, 2008 The biases of individual algorithms for non-parametric document clustering can lead to non-optimal solutions. Ensemble clustering methods may overcome this limitation, but have not been applied to document collections.
González Pellicer, Edgar +1 more
core +1 more source
An innovative approach based on real-world big data mining for calculating the sample size of the reference interval established using transformed parametric and non-parametric methods. [PDF]
BMC Med Res Methodol, 2022 Ma C +8 more
europepmc +1 more source