Results 191 to 200 of about 9,424,993 (263)

Structural themes of cereblon‐recruiting degraders: selected recent examples

Acta Crystallographica Section F, EarlyView.
Structural studies of cereblon‐recruiting degrader complexes have transformed our understanding of targeted protein degradation. This review discusses selected examples of how X‐ray crystallography and cryogenic‐electron microscopy have enabled the structure‐guided optimization of heterobifunctional degraders and molecular‐glue degraders.
Sana Ahmed, Michael Rowley
wiley   +1 more source

Design of peptides with noncanonical amino acids using flow matching. [PDF]

Bioinformatics
Lee JS, Kim PM.
europepmc   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Clinical and Molecular Delineation of <i>KAT6B</i>-Related Disorders: Novel Variants and Refined Genotype-Phenotype Correlations. [PDF]

Hum Mutat
Colona VL, Gnazzo M, Donato A, Fioretti L, Terracciano A, Monopoli D, Buonuomo PS, Gonfiantini MV, Lettori D, Taurisano R, Mazza T, Concolino D, Mucciolo M, Macchiaiolo M, Novelli A, Vecchio D.   +15 more
europepmc   +1 more source

Full‐length transcriptome profiling of true bug mitochondrial genomes reveals the unique transcriptional regulation during insect evolution

Insect Science, EarlyView.
The mitogenome was transcribed into complete primary polycistrons on both strands. The heteropteran mitochondrial transcription termination factor (HmTTF) functions as a bidirectional attenuator rather than a terminator, and co‐evolution of HmTTF and the binding sites was observed.
Shiwen Xu, Yuange Duan, Ling Ma, Qiaoqiao Liu, Fan Song, Wanzhi Cai, Hu Li   +6 more
wiley   +1 more source

<i>Parahenipavirus langyaense</i> (Langya virus): Spillover ecology, noncanonical receptor-mediated entry, and future control strategies. [PDF]

One Health
Shen L, Tong Y, Chai W, Sun J, Zhao J, Yin L, Yang Y, Wang C, Tan W, Zhang J.   +9 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Cellular and Humoral Immune Responses to Noncanonical Enterotoxigenic Escherichia coli Virulence Factors. [PDF]

Eur J Immunol
Riaz S, Rim S, Steinsland H, Vedøy OB, Vickers TJ, Fleckenstein JM, Hanevik K.   +6 more
europepmc   +1 more source

Distinct Clinicogenomic Contexts of BRAF‐Altered Gliomas and Glioneuronal Tumors: A Nationwide Real‐World Study

Cancer Science, EarlyView.
Nationwide real‐world profiling revealed distinct clinicogenomic contexts across major BRAF alteration classes in gliomas and glioneuronal tumors. KIAA1549::BRAF fusion was associated with younger age and predominantly low‐grade tumors, whereas BRAF amplification‐only tumors were predominantly high‐grade and showed frequent MET amplification.
Seiji Yamada, Tetsuya Takimoto, Sayaka Ueno, Sachiko Minamiguchi, Shigeo Ohba, Yuichi Hirose, Hideyuki Saya, Tamotsu Sudo   +7 more
wiley   +1 more source

Exploring Secondary Structure Predictions for RNA-Targeted Drug Discovery: Power and Challenges. [PDF]

J Chem Inf Model
Zhang Z, Dolcetti G, Tyrchan C, De Maria L, Bussi G, Czechtizky W.   +5 more
europepmc   +1 more source