Results 31 to 40 of about 49,716 (243)

Measuring the completeness of death registration in 2844 Chinese counties in 2018

BMC Medicine, 2020
Background Death registration completeness has never been assessed at the county level in China. Such analyses would provide critical intelligence to monitor the performance of the vital registration system and yield adjustment factors to correct death ...
Xinying Zeng, Tim Adair, Lijun Wang, Peng Yin, Jinlei Qi, Yunning Liu, Jiangmei Liu, Alan D. Lopez, Maigeng Zhou   +8 more
doaj   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Effect of short-term intensive brisk walking prescription on obesity in Chinese occupational population: a pair matched-control study

Zhongguo gonggong weisheng, 2022
ObjectiveTo evaluate intervention effect of intensive brisk walking prescription on obesity in Chinese occupational population and to provide a reference for popularizing appropriate weight control program among occupational population in China ...
Kai-ming GUO, Yi-fan ZHAO, Ping-ping ZHAO, Yong-qing LIN   +3 more
doaj   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Effect of brisk walking intervention in occupational populations with normal high blood pressure: an isotemporal substitution model-based analysis

Zhongguo gonggong weisheng, 2023
ObjectiveTo examine the effect of brisk walking intervention in occupational populations with normal high blood pressure, and to provide quantified evidence for health improvement of occupational population with normal high blood pressure.
Kaiming GUO, Yifan ZHAO, Pingping ZHAO, Fang LIU, Xi XU, Chao ZHANG, Maigeng ZHOU, Wei JIANG   +7 more
doaj   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

The detection rate of high-risk groups for different subtypes of cardiovascular diseases and its influencing factors in Shaanxi province

Zhongguo gonggong weisheng
ObjectiveTo investigate the detection rate of different subtypes of cardiovascular disease (CVD) high-risk populations in Shaanxi province and their influencing factors, so as to provide a scientific basis for the prevention and control of CVD ...
Kaiming GUO, Zhiping HU, Rong LIU, SARINA, Lin QIU   +4 more
doaj   +1 more source

Monitoring of noncommunicable diseases [PDF]

Journal of Social Health and Diabetes, 2016
AbstractNoncommunicable diseases (NCDs) represent a major fraction of the global health burden in terms of morbidity and mortality, and its prevalence is on the rise across the world. As more and more people are living with various NCD, primary and secondary prevention becomes an important tool to contain this impending epidemic.
Sandeep Kumar, Vivek Aggarwal, K. Hari Kumar   +2 more
openaire   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source