Results 101 to 110 of about 39,128 (274)

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

open access: yesBrain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma   +12 more
wiley   +1 more source

Yellow Fever Virus in Haemagogus leucocelaenus and Aedes serratus Mosquitoes, Southern Brazil, 2008

open access: yesEmerging Infectious Diseases, 2010
Yellow fever virus (YFV) was isolated from Haemagogus leucocelaenus mosquitoes during an epizootic in 2001 in the Rio Grande do Sul State in southern Brazil.
Jáder da C. Cardoso   +13 more
doaj   +1 more source

Frameless stereotaxy in the nonhuman primate

open access: yesNeuroImage, 2004
With the advent of magnetic resonance imaging (MRI), it is possible to obtain high-resolution anatomical images of the monkey brain. Accuracy, however, is lost in the laboratory or surgical setting when the localization of brain structures depends on nonstereotaxic tracking methods.
Stephen Frey   +4 more
openaire   +2 more sources

Drivers of bat researchers’ intent to adopt field hygiene practices

open access: yesConservation Biology, EarlyView.
Abstract Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate
Joanna L. Coleman   +6 more
wiley   +1 more source

Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates

open access: yesProceedings of the Japan Academy. Series B, Physical and Biological Sciences
Nonhuman primates, particularly macaque and marmoset monkeys, serve as invaluable models for studying complex brain functions and behavior. However, the lack of suitable genetic neuromodulation tools has constrained research at the network level.
Takafumi MINAMIMOTO   +2 more
doaj   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

open access: yesThe FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka   +3 more
wiley   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

open access: yesThe FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki   +7 more
wiley   +1 more source

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection

open access: yes, 2009
Background: There is currently no effective AIDS vaccine, emphasizing the importance of developing alternative therapies. Recently, a patient was successfully transplanted with allogeneic, naturally resistant CCR5-negative (CCR5 delta 32) cells, setting ...
Trobridge, Grant D.   +28 more
core   +1 more source

CD49a expression defines a metabolically robust, cytokine‐biased liver NK cell subset in rhesus macaques during lentivirus infection

open access: yesImmunology &Cell Biology, EarlyView.
Liver‐resident NK cells (CD49a+ NK cells) in rhesus macaques display distinct activating receptor and metabolic markers enhanced phenotype compared with hepatic NK cell subsets (CD49a−) in the liver. These cells exhibit heightened cytokine polyfunctionality with restrained cytotoxic responses upon mitogen stimulation in comparison with CD49a− NK cell ...
Andrew Hudson   +4 more
wiley   +1 more source

Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects

open access: yes, 2018
Joshua D Vardigan, Andrea K Houghton, Henry S Lange, Emily D Adarayan, Parul S Pall, Jeanine E Ballard, Darrell A Henze, Jason M Uslaner Merck Research Laboratories, West Point, PA, USA Introduction: The development of novel ...
Lange HS   +7 more
core  

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