Results 81 to 90 of about 39,128 (274)

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Correlation between Disease Severity and the Intestinal Microbiome in Mycobacterium tuberculosis-Infected Rhesus Macaques

mBio, 2019
The factors that determine host susceptibility to tuberculosis (TB) are poorly defined. The microbiota has been identified as a key influence on the nutritional, metabolic, and immunological status of the host, although its role in the pathogenesis of TB
Sivaranjani Namasivayam, Keith D. Kauffman, John A. McCulloch, Wuxing Yuan, Vishal Thovarai, Lara R. Mittereder, Giorgio Trinchieri, Daniel L. Barber, Alan Sher   +8 more
doaj   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

iMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang, Xiaopeng Wang, Peng Li, Junyu Zhang, Wenjie Sun, Zhen Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen   +8 more
wiley   +1 more source

Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics

BMC Genomics
Background Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with humans, serve as an ideal model for ...
Yunpeng Liu, Shuaiyao Lu, Jing Yang, Yun Yang, Li Jiao, Jingwen Hu, Yanyan Li, Fengmei Yang, Yunli Pang, Yuan Zhao, Yanpan Gao, Wei Liu, Pengcheng Shu, Wei Ge, Zhanlong He, Xiaozhong Peng   +15 more
doaj   +1 more source

Mycobacterium leprae genomes from naturally infected nonhuman primates.

PLoS Neglected Tropical Diseases, 2018
Leprosy is caused by the bacterial pathogens Mycobacterium leprae and Mycobacterium lepromatosis. Apart from humans, animals such as nine-banded armadillos in the Americas and red squirrels in the British Isles are naturally infected with M.
Tanvi P Honap, Luz-Andrea Pfister, Genevieve Housman, Sarah Mills, Ross P Tarara, Koichi Suzuki, Frank P Cuozzo, Michelle L Sauther, Michael S Rosenberg, Anne C Stone   +9 more
doaj   +1 more source

Diverse Contexts of Zoonotic Transmission of Simian Foamy Viruses in Asia

Emerging Infectious Diseases, 2008
In Asia, contact between persons and nonhuman primates is widespread in multiple occupational and nonoccupational contexts. Simian foamy viruses (SFVs) are retroviruses that are prevalent in all species of nonhuman primates.
Lisa Jones-Engel, Cynthia C. May, Gregory A. Engel, Katherine A. Steinkraus, Michael A. Schillaci, Agustin Fuentes, Aida Rompis, Mukesh K. Chalise, Nantiya Aggimarangsee, Mohammed M. Feeroz, Richard Grant, Jonathan S. Allan, Arta Putra, I. Nengah Wandia, Robin Watanabe, LaRene Kuller, Satawat Thongsawat, Romanee Chaiwarith, Randall C. Kyes, Maxine L. Linial   +19 more
doaj   +1 more source

The Primate Information Center - Unique resource of nonhuman primate literature

, 1992
The Primate Information Center (PIC) is a unique bibliographic and reference service for researchers, primatologists, laboratory animal, zoo, exotic animal veterinarians.
Johnson-Delaney, Cathy
core   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source