Results 111 to 120 of about 72,059 (284)
A Case for Anti‐IgE Vaccination
Allergy, EarlyView.ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff +3 more
wiley +1 more source
Three‐dimensional patient‐derived endometriosis model for drug evaluation
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.In this study, we developed a coculturing model with stromal cells and epithelial organoids to mimic the endometriotic lesion and for further evaluation of drug effects. Abstract Introduction Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms.
Yuqi Li +10 more
wiley +1 more source
Development of a Swine Whole Eye Transplant Ex Vivo Perfusion Protocol
Artificial Organs, EarlyView.This study establishes the first subnormothermic machine perfusion protocol for whole eye transplants in a swine model, enabling up to 18 h of preservation with stable metabolic function, limited edema, and recovery of mydriasis. ABSTRACT Background The first human Whole Eye Transplant (WET) has sparked new hope for patients who have lost vision due to
Haïzam Oubari +8 more
wiley +1 more source
Cell Transplantation, 2000 Transplantation of pancreatic islets of Langerhans as a therapeutic approach for treatment of type I diabetes offers an alternative to subcutaneous insulin injections.
Alessandra Rammcoli +7 more
doaj +1 more source
Clarification and confocal imaging of the nonhuman primate placental micro-anatomy
BioTechniques, 2019 Geometry of the placental villous vasculature is a key determinant of maternal–fetal nutrient exchange for optimal fetal growth. Recent advances in tissue clarification techniques allow for deep high-resolution imaging with confocal microscopy; however ...
JA Sargent +3 more
doaj +1 more source
Lithic analysis in African archaeology: Advances and key themes
Archaeometry, EarlyView.Abstract Stone artifacts (lithics) preserve for extended periods; thus they are key evidence for probing the evolution of human technological behaviors. Africa boasts the oldest record of stone artifacts, spanning 3.3 Ma, rare instances of ethnographic stone tool‐making, and stone tool archives from diverse ecological settings, making it an anchor for ...
Deborah I. Olszewski +2 more
wiley +1 more source
Yellow Fever Virus in Haemagogus leucocelaenus and Aedes serratus Mosquitoes, Southern Brazil, 2008
Emerging Infectious Diseases, 2010 Yellow fever virus (YFV) was isolated from Haemagogus leucocelaenus mosquitoes during an epizootic in 2001 in the Rio Grande do Sul State in southern Brazil.
Jáder da C. Cardoso +13 more
doaj +1 more source
Archaeometry, EarlyView.Abstract The use of stone hammers to produce sharp stone flakes—knapping—is thought to represent a significant stage in hominin technological evolution because it facilitated the exploitation of novel resources, including meat obtained from medium‐to‐large‐sized vertebrates. The invention of knapping may have occurred via an additive (i.e., cumulative)
Metin I. Eren +23 more
wiley +1 more source
Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesNonhuman primates, particularly macaque and marmoset monkeys, serve as invaluable models for studying complex brain functions and behavior. However, the lack of suitable genetic neuromodulation tools has constrained research at the network level.
Takafumi MINAMIMOTO +2 more
doaj +1 more source
BMC Genomics, 2012 Background African Green Monkeys (AGM) are amongst the most frequently used nonhuman primate models in clinical and biomedical research, nevertheless only few genomic resources exist for this species.
Tchitchek Nicolas +8 more
doaj +1 more source