Results 101 to 110 of about 111,518 (268)

A single center’s experience with noninvasive prenatal testing [PDF]

Genetics in Medicine, 2014
Massively parallel sequencing to detect fetal aneuploidy has high sensitivity and specificity for the detection of trisomies 21, 18, and 13 in high-risk populations. The purpose of our study was to review our institution's experience with the use of noninvasive prenatal testing for aneuploidy screening.This was a descriptive study of patients who had ...
Carmen J, Beamon, Emily E, Hardisty, Sarah C, Harris, Neeta L, Vora   +3 more
openaire   +2 more sources

Hypertensive retinopathy in pre‐eclampsia and its association with disease severity and neonatal outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Introduction Pre‐eclampsia (PE) involves systemic endothelial dysfunction and microvascular injury, yet routine obstetric care lacks noninvasive readouts of maternal microvascular health. We evaluated whether hypertensive retinopathy (HR) detected during pregnancy is associated with maternal disease severity and adverse neonatal outcomes ...
Gabriele Saccone, Francesco Matarazzo, Mariarosaria Motta, Marika Rovetto, Michele Rinaldi, Maurizio Guida, Ciro Costagliola   +6 more
wiley   +1 more source

Routine Fetal Rhd Genotyping with Maternal Plasma: A Four-Year Experience in Belgium [PDF]

, 2008
peer reviewedBACKGROUND: The objective was to evaluate the diagnostic value of RHD fetal genotyping from the plasma of D- mothers as soon as 10 weeks' gestation in a routine clinical practice in Belgium.
Bianchi DW, Colin Y, Cortey A, Daniels G, Flegel WA, Flegel WA, Grootkerk MG, Judd WJ, Legler J, Mannessier L, Minon JM, Moise KJ, Moise KJ, Singleton BK, Wagner FF, Wagner FF   +15 more
core   +1 more source

Noninvasive Prenatal Testing: The Indian Perspective [PDF]

Journal of Fetal Medicine, 2014
AbstractThis article summarizes the Professor Kamal Buckshee Oration given by the author at the annual conference of the Society of Fetal Medicine in Kochi, August 2014. The contributions of Professor Buckshee to fetal medicine are briefly described. The article traces the development of fetal medicine in India.
openaire   +1 more source

Pregnancy Outcomes and Postnatal Health From Transferred Mosaic Embryos Following Preimplantation Genetic Testing for Aneuploidy

iNew Medicine, EarlyView.
This illustration synthesizes the methods and conclusion of this study, demonstrating that the transfer of mosaic embryos following reimplantation genetic testing for aneuploidy does not increase the risk to postnatal health. ABSTRACT Next‐generation sequencing (NGS) has increased the detection of mosaic embryos during preimplantation genetic testing ...
Lili Chen, Dehuan Huang, Jingcheng Sang, Yiqi Yin, Caiyun Wu, Yan Hao, Dawei Chen, Zhiguo Zhang, Yunxia Cao, Ri‐Cheng Chian, Ping Zhou   +10 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Ultrasound and SNP-based cell-free DNA zygosity testing in twin pregnancies

The Journal of Maternal-Fetal & Neonatal Medicine
Introduction The importance of prenatal determination of chorionicity for the management of twin pregnancies is well recognized. However, research on the contribution of prenatal evaluation of zygosity to the management of twins is limited.
Ruben Quintero, K. Joseph Hurt, Neeta L. Vora, Neil S. Seligman, Gerard P. Reilly, Myra J. Wick, Samuel B. Wolf, Maeve Hopkins, Thomas Westover, Homa K. Ahmadzia, Camille Kanaan, Andrei Rebarber, Eftichia V. Kontopoulos, Jingwen Zhang, Melissa Egbert, Sophia Vourthis, Ashley Cantu-Weinstein, Jessica L. Saben, Russ Jelsema, Vivienne Souter, Clark T. Johnson, Peter Benn   +21 more
doaj   +1 more source

Application value of NIPT for uncommon fetal chromosomal abnormalities

Molecular Cytogenetics, 2020
Objective To investigate the clinical value of noninvasive prenatal testing (NIPT) for fetal chromosomal deletion, duplication, and sex chromosome abnormalities.
Lianli Yin, Yinghua Tang, Qing Lu, Aiping Pan, Mingfang Shi   +4 more
doaj   +1 more source

Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down's syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units. [PDF]

, 2016
OBJECTIVE:  To investigate the benefits and costs of implementing non-invasive prenatal testing (NIPT) for Down's syndrome into the NHS maternity care pathway. DESIGN:  Prospective cohort study.
Cameron, L, Chitty, LS, Daley, R, Fisher, J, Hill, M, Howarth, A, Jenkins, L, Kroese, M, Lewis, C, Mason, S, McEwan, A, McKay, F, Morris, S, Verhoef, TI, Wright, D   +14 more
core   +1 more source