Results 211 to 220 of about 111,518 (268)

Clinical application of expanded noninvasive prenatal testing for fetal chromosome abnormalities in a cohort of 39,580 pregnancies

American Journal of Medical Genetics. Part A, 2022
The aim of this study was to determine the predictive value of expanded noninvasive prenatal testing (NIPT‐plus) for fetal chromosome abnormalities in the second trimester (12–26 weeks).
Yisheng Chen, Loukaiyi Lu, Ying Zhang, Feifei Wang, Y. Ni, Qiang Wang, Chunmei Ying   +6 more
semanticscholar   +1 more source

Digital PCR and its applications in noninvasive prenatal testing.

Briefings in Functional Genomics, 2022
In the past decade, digital PCR (dPCR), as a new nucleic acid absolute quantification technology, has been widely used in clinical research. dPCR does not rely on the standard curve and has a higher tolerance to inhibitors. Therefore, it is more accurate
Yue-Qi Li, Gongjun Tan, Yu-Qiu Zhou
semanticscholar   +1 more source

Maternal Malignancies Detected With Noninvasive Prenatal Testing

JAMA, 2015
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Sistermans, E., Straver, R., Faas, B.H.W.   +2 more
openaire   +4 more sources

Noninvasive prenatal testing: need for informed enthusiasm

American Journal of Obstetrics and Gynecology, 2014
ells trafficking between the maternal and fetal com1 prenatal panel.” Recent studies are supportive of this 11,12 C partments was first noted in 1893 by Schmorl. The ability to quantify and analyze these fetal cells using cell sorting and polymerase chain reaction was not developed until approximately 1 century later.
Christina S. Han, Lawrence D. Platt
openaire   +2 more sources

Insights into Noninvasive Prenatal Testing Performance: A 4365-sample Analysis of Diagnostic and Quality Control Outcomes

SBV Journal of Basic, Clinical and Applied Health Science
Noninvasive prenatal testing (NIPT) is a transformative tool in prenatal care, offering early detection of chromosomal abnormalities with high accuracy.
J. Dewantiningrum, W. Andonotopo, M. A. Bachnas, M. B. A. Pramono, I. N. H. Sanjaya, Ernawati Darmawan, Dudy Aldiansyah, Milan Stanojević, A. Kurjak   +8 more
semanticscholar   +1 more source

Clinical Implications of Noninvasive Prenatal Testing Failures Due to Low Fetal Fraction: Associations With Adverse Maternal and Fetal Outcomes

Prenatal Diagnosis
To identify risk factors associated with noninvasive prenatal testing (NIPT) failures due to a low fetal fraction (LFF, < 4%) and to evaluate appropriate management strategies.
Yuan Ren, N. Hao, Jiazhen Chang, Yulin Jiang, Qingwei Qi, Xiya Zhou, Jingwen Zhou, Yingna Song, Juntao Liu   +8 more
semanticscholar   +1 more source

Jacobsen Syndrome Detected by Noninvasive Prenatal Testing

Obstetrics & Gynecology, 2015
Noninvasive prenatal testing has a high detection rate of common fetal chromosomal aneuploidies. However, detection of additional chromosome abnormalities has not been well described or validated.We report a case of Jacobsen syndrome, a congenital disorder involving deletion of chromosome 11q, detected by noninvasive prenatal testing at 14 weeks of ...
Jamie O, Lo, Cori D, Feist, Jason, Hashima, Brian L, Shaffer   +3 more
openaire   +2 more sources

A Forward Look At Noninvasive Prenatal Testing

Trends in Molecular Medicine, 2016
Genomic abnormalities are a leading cause of birth defects and pregnancy complications, including in utero growth retardation and risk of miscarriage. Traditional invasive methods detecting such genomic abnormalities pose a relative risk to mother and unborn fetus. Non-invasive prenatal testing (NIPT) is a method that determines the genomic status of a
Li, Liu, Kang, Li, Xin, Fu, Christopher, Chung, Kang, Zhang   +4 more
openaire   +2 more sources

A New Era in Noninvasive Prenatal Testing

New England Journal of Medicine, 2013
Cell-free fetal DNA testing permits earlier detection of common trisomies and generally provides earlier information about a fetus's sex. But with its clinical utility in the general population uncertain, such testing is drifting into routine practice ahead of the evidence.
Stephanie, Morain, Michael F, Greene, Michelle M, Mello   +2 more
openaire   +5 more sources

Critical appraisal of droplet digital polymerase chain reaction application for noninvasive prenatal testing

Congenital Anomalies, 2022
Maternal‐fetal medicine (FM) is currently a highly demanding branch and is gaining importance as increasing number of genetic disorders rise in incidence.
D. S. Shekhawat, Charu Sharma, Kuldeep Singh, Pratibha Singh, Abhishek Bhardwaj, Payal Patwa   +5 more
semanticscholar   +1 more source