Results 31 to 40 of about 1,563,210 (304)

Whale optimization algorithm with nonlinear control parameter

open access: yesMATEC Web of Conferences, 2017
Whale optimization algorithm (WOA) is a relatively novel intelligence optimization technique which has been shown to be competitive to other population-based algorithms.
Zhong Minghui, Long Wen
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Nonlinear error correction, asymmetric adjusment and cointegration [PDF]

open access: yes, 1991
This paper has three main components. First, it outlines a model of nonlinear error correction (NEC) in which the linear error correction term a'Xt (the vector time series Xt is cointegrated, a is the cointegrating vector) is replaced by the nonlinear ...
Pfann, Gerard, Escribano, Álvaro
core   +1 more source

Optical bistability in two-dimensional nonlinear composites of coated cylinders with nonlinear core and graded shell

open access: yesEPJ Applied Metamaterials, 2020
The intrinsic optical bistability of the nonlinear composite consisting of coated cylinders with nonlinear core and graded Drude shell is investigated with self-consistent mean-field approximation.
Wu Ya M.   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Particle Filter Design for Robust Nonlinear Control System of Uncertain Heat Exchange Process with Sensor Noise and Communication Time Delay

open access: yesApplied Sciences, 2022
In this paper, a particle filter design scheme for a robust nonlinear control system of uncertain heat exchange process against noise and communication time delay is presented.
Yuanhong Xu, Mingcong Deng
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Global Distribution Adjustment and Nonlinear Feature Transformation for Automatic Colorization

open access: yesAdvances in Multimedia, 2018
Automatic colorization is generally classified into two groups: propagation-based methods and reference-based methods. In reference-based automatic colorization methods, color image(s) are used as reference(s) to reconstruct original color of a gray ...
Terumasa Aoki, Van Nguyen
doaj   +1 more source

Research on parallel control of CMAC and PD based on U model

open access: yesAutomatika, 2021
In this paper, the nonlinear U model with time-varying coefficients is investigated and the transformation of the nonlinear model is accomplished by the Newton iterative algorithm. Based on the nonlinear U model, a control algorithm with cerebellar model
Fengxia Xu   +4 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

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