Results 41 to 50 of about 147,026 (262)

Nonlinear Fractional q-Difference Equation with Fractional Hadamard and Quantum Integral Nonlocal Conditions

Journal of Function Spaces, 2020
In this paper, we establish existence and uniqueness results for a boundary value problem consisting by a nonlinear fractional q-difference equation subject to a new type of boundary condition, combining the fractional Hadamard and quantum integrals. Our
Athasit Wongcharoen, Arisa Thatsatian, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
doaj   +1 more source

Which Alternative for Solving Dual Fuzzy Nonlinear Equations Is More Precise?

Mathematics, 2020
To answer the question stated in the title, we present and compare two approaches: first, a standard approach for solving dual fuzzy nonlinear systems (DFN-systems) based on Newton’s method, which uses 2D FN representation and second, the new approach ...
Joanna Kołodziejczyk, Andrzej Piegat, Wojciech Sałabun   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Positive Solutions for System of Nonlinear Fractional Differential Equations in Two Dimensions with Delay

Abstract and Applied Analysis, 2010
We investigate the existence and uniqueness of positive solution for system of nonlinear fractional differential equations in two dimensions with delay. Our analysis relies on a nonlinear alternative of Leray-Schauder type and Krasnoselskii's fixed point
Azizollah Babakhani
doaj   +1 more source

Existence of Solutions in a Cone for Nonlinear Alternative Problems [PDF]

Proceedings of the American Mathematical Society, 1985
Using the alternative method we present sufficient conditions for the existence of positive solutions to nonlinear equations at resonance and extend a well-known result of Cesari and Kannan.
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Capacity estimates for optical transmission based on the nonlinear Fourier transform

Nature Communications, 2016
Optical fibres enable high-speed communication over long distances, but traditional systems are limited by nonlinear optical effects. Here, the authors quantify the increase in capacity that is made possible by using an alternative approach that uses a ...
Stanislav A. Derevyanko, Jaroslaw E. Prilepsky, Sergei K. Turitsyn   +2 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Geometrical nonlinearity of circular plates and membranes: An alternative method [PDF]

Journal of Applied Physics, 2020
We apply the well-established theoretical method developed for geometrical nonlinearities of micro-/nano-mechanical clamped beams to circular drums. The calculation is performed under the same hypotheses, the extra difficulty being to analytically describe the (coordinate-dependent) additional stress generated in the structure by the motion ...
Cattiaux, D., Kumar, S., Zhou, Xin, Fefferman, A., Collin, E.   +4 more
openaire   +4 more sources