Results 41 to 50 of about 137,445 (262)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
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Electronic Journal of Differential Equations, 2008 This article shows sufficient conditions for the existence of mild solutions, on the positive half-line, for two classes of first-order functional and neutral functional perturbed differential evolution equations with infinite delay.
Mouffak Benchohra, Selma Baghli
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A finite-difference method for linearization in nonlinear estimation algorithms [PDF]
Modeling, Identification and Control, 1998 Linearizations of nonlinear functions that are based on Jacobian matrices often cannot be applied in practical applications of nonlinear estimation techniques. An alternative linearization method is presented in this paper.
Tor S. Schei
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Mathematics, 2021 In this paper, the authors propose an investigation of the existence of solutions for a system of nonlinear Hadamard-type integro-differential equations in a Banach space.
Chenkuan Li +2 more
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Nonlinear analysis in p-vector spaces for single-valued 1-set contractive mappings
Fixed Point Theory and Algorithms for Sciences and Engineering, 2022 The goal of this paper is to develop some fundamental and important nonlinear analysis for single-valued mappings under the framework of p-vector spaces, in particular, for locally p-convex spaces for 0 < p ≤ 1 $0 < p \leq 1$ .
George Xianzhi Yuan
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Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
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Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis
Arthritis Care &Research, Accepted Article.Background/Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs Rheumatoid Arthritis (VARA) Registry.
Katherine D. Wysham +14 more
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