Results 31 to 40 of about 339,215 (316)

A posteriori error estimates of hp spectral element method for parabolic optimal control problems

open access: yesAIMS Mathematics, 2022
In this paper, we investigate the spectral element approximation for the optimal control problem of parabolic equation, and present a hp spectral element approximation scheme for the parabolic optimal control problem.
Zuliang Lu   +5 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Nonlinear Active Noise Control

open access: yes, 2004
Publication in the conference proceedings of EUSIPCO, Viena, Austria ...
SICURANZA, GIOVANNI, A. CARINI
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Enhanced tunable fracture properties of the high stiffness hierarchical honeycombs with stochastic Voronoi substructures

open access: yesResults in Physics, 2019
For multifunctional optimization design of honeycomb structures, the high stiffness hierarchical honeycombs with stochastic Voronoi substructures (HHSVS) are proposed by substituting cell walls of the regular hexagonal honeycombs (ORHH) with Voronoi ...
Bin Wang   +6 more
doaj   +1 more source

Inverse Optimal Control in State Derivative Space System with Applications in Motor Control

open access: yesEnergies, 2021
This paper mathematically explains how state derivative space (SDS) system form with state derivative related feedback can supplement standard state space system with state related feedback in control designs.
Feng-Chi Lee   +4 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Dynamic Modeling and Structural Optimization of a Bistable Electromagnetic Vibration Energy Harvester

open access: yesEnergies, 2019
A novel bistable electromagnetic vibration energy harvester (BEMH) is constructed and optimized in this study, based on a nonlinear system consisting mainly of a flexible membrane and a magnetic spring.
Bei Zhang   +6 more
doaj   +1 more source

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