Results 41 to 50 of about 1,307,908 (292)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Comparison of Deep Learning and Deterministic Algorithms for Control Modeling
Sensors, 2022 Controlling nonlinear dynamics arises in various engineering fields. We present efforts to model the forced van der Pol system control using physics-informed neural networks (PINN) compared to benchmark methods, including idealized nonlinear feedforward (
Hanfeng Zhai, Timothy Sands
doaj +1 more source
Nonsquare Spectral Factorization for Nonlinear Control Systems [PDF]
, 2005 This paper considers nonsquare spectral factorization of nonlinear input affine state space systems in continuous time. More specifically, we obtain a parametrization of nonsquare spectral factors in terms of invariant Lagrangian submanifolds and ...
Petersen, Mark A., +1 more
core +2 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
Hoist-Based Shape Memory Alloy Actuator with Multiple Wires for High-Displacement Applications
Actuators, 2023 Shape memory alloys (SMAs) are smart materials that change their crystalline structures when subjected to heat or tension, resulting in a macroscopic deformation.
Carmen Ballester +4 more
doaj +1 more source
H∞ Control of Nonlinear Systems: A Class of Controllers [PDF]
, 1993 The standard state space solutions to the H∞ control problem for linear time invariant systems are generalized to nonlinear time-invariant systems.
Doyle, John C., Lu, Wei-Min
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Results in Physics, 2019 For multifunctional optimization design of honeycomb structures, the high stiffness hierarchical honeycombs with stochastic Voronoi substructures (HHSVS) are proposed by substituting cell walls of the regular hexagonal honeycombs (ORHH) with Voronoi ...
Bin Wang +6 more
doaj +1 more source
Control of nonlinear underactuated systems
, 1999 In this paper we introduce a new method to design control laws for non-linear underactuated systems. Our method produces an infinite dimensional family of control laws, whereas most control techniques only produce a finite dimensional family.
Auckly, Dave +2 more
core +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source